Targeting cytochrome P450 enzymes: a new approach in anti-cancer drug development.
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TLDR
This review offers the first comprehensive analysis of strategies in drug development that either inhibit or exploit CYP enzymes for the treatment of cancer.About:
This article is published in Bioorganic & Medicinal Chemistry.The article was published on 2007-08-01 and is currently open access. It has received 229 citations till now. The article focuses on the topics: Cytochrome P-450 Enzyme Inhibitors & Cancer.read more
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A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry.
TL;DR: This work systematically gives a comprehensive review in current developments of BTA-based compounds in the whole range of medicinal chemistry as anticancer, antibacterial, antifungal, antiinflammatory, analgesic, anti-HIV, antioxidant, anticonvulsant, antitubercular, antidiabetic, antileishmanial, antihistaminic, antimalarial and other medicinal agents.
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PGRMC1 (progesterone receptor membrane component 1): a targetable protein with multiple functions in steroid signaling, P450 activation and drug binding.
TL;DR: Together with its biological role in promoting tumor survival, PGRMC1 is an attractive target for therapeutic intervention in cancer and related malignancies.
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CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma
Elisa M. Noll,Christian Eisen,Albrecht Stenzinger,Albrecht Stenzinger,Elisa Espinet,Alexander Muckenhuber,Corinna Klein,Vanessa Vogel,Bernd Klaus,Wiebke Nadler,Christoph Rösli,Christian Lutz,Michael Kulke,Jan Engelhardt,Franziska M. Zickgraf,Octavio Espinosa,Matthias Schlesner,Xiaoqi Jiang,Annette Kopp-Schneider,Peter Neuhaus,Marcus Bahra,Bruno Valentin Sinn,Roland Eils,Roland Eils,Nathalia Giese,Thilo Hackert,Oliver Strobel,Jens Werner,Markus W. Büchler,Wilko Weichert,Andreas Trumpp,Martin R. Sprick +31 more
TL;DR: CYP3A5 is designated as a predictor of therapy response and as a tumor cell–autonomous detoxification mechanism that must be overcome to prevent drug resistance in pancreatic ductal adenocarcinoma.
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Cytochrome P450-derived eicosanoids: the neglected pathway in cancer
TL;DR: The emerging role in cancer of cytochrome P450 metabolites, notably 20-HETE and EETs, are discussed.
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Structural Characterization of the Complex between α-Naphthoflavone and Human Cytochrome P450 1B1
TL;DR: The atomic structure of human P450 1B1 was determined by x-ray crystallography to 2.7 Å resolution with α-naphthoflavone bound in the active site cavity with sequence divergence around the edges of the cavity that modify substrate and inhibitor binding.
References
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Studies on prostatic cancer: I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate
TL;DR: Gutman et al. as mentioned in this paper showed that the acid phosphatase of serum is reduced in metastatic carcinoma of the prostate by decreasing the activity of androgens through castration or estrogenic injections and that this enzyme is increased by injecting androgens.
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Studies on Prostatic Cancer. I. The Effect of Castration, of Estrogen and of Androgen Injection on Serum Phosphatases in Metastatic Carcinoma of the Prostate
TL;DR: It is demonstrated that a marked rise in acid phosphatase in serum is associated with the appearance or spread of roentgenologically demonstrable skeletal metastases and implies dissemination of the primary tumor and thus is of unfavorable prognostic significance.
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A decade of molecular biology of retinoic acid receptors.
TL;DR: A review of recent developments in structure‐ function relationships of retinoic acid receptors focuses on recent developments, particularly in the area of structure‐function relationships.
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Molecular determinants of resistance to antiandrogen therapy
Charlie D. Chen,Derek S. Welsbie,Chris Tran,Sung Hee Baek,Randy Chen,Robert L. Vessella,Michael G. Rosenfeld,Charles L. Sawyers +7 more
TL;DR: Using microarray-based profiling of isogenic prostate cancer xenograft models, it is found that a modest increase in androgen receptor mRNA was the only change consistently associated with the development of resistance to antiandrogen therapy.
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Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals.
Michael S. Denison,Scott R. Nagy +1 more
TL;DR: Evidence for the structural promiscuity of AhR ligand binding is described and the current state of knowledge with regards to the activation of the AhR signaling pathway by naturally occurring exogenous and endogenous ligands is discussed.