Showing papers in "The Journal of Steroid Biochemistry and Molecular Biology in 2011"

TL;DR: Although many questions remain to be answered, it is becoming increasingly apparent that exposure to BPA is ubiquitous and that the effects of this endocrine disruptor are complex and wide-ranging.

TL;DR: This review focuses on the mechanisms and modes of action by which EDCs alter hormone signaling, and includes brief overviews of select disease endpoints associated with endocrine disruption.

TL;DR: The case for atrazine as an endocrine disruptor that demasculinizes and feminizes male vertebrates meets all nine of the "Hill criteria" for establishing cause-effect relationships.

TL;DR: Three aromatase inhibitors (AIs) are now FDA approved and have been shown to be more effective than the antiestrogen tamoxifen and are well tolerated and are now a standard treatment for postmenopausal patients.

TL;DR: An isosteric G-1 derivative, G36, containing an isopropyl moiety in place of the ethanone moiety is synthesized, demonstrating that G36 shows decreased binding and activation of ERα, while maintaining its antagonist profile towards GPER.

TL;DR: The existing literature on the known health effects of PFOA in animal models is reviewed, focusing on sensitive developmental periods, and epidemiologic health data is presented, with the caveat that these studies largely address only associations between adult exposures and outcomes.

TL;DR: In overweight and obese persons a change in the metabolism of xenobiotics is observed, possibly implying that this group of consumers is insufficiently protected by current risk assessment practice, and routine testing for EDCs and an assessment of the whole migrate toxicity of a food packaging are recommended, taking into account all sensitive population groups.

TL;DR: An overview of functional and structural aspects for the different 17β-HSDs is given and the selective inhibition of the concerned enzymes might provide an effective treatment and a good alternative to the existing endocrine therapies.

TL;DR: The role of androgen biosynthesis in the progression of prostate cancer and the impact of CYP17 inhibitors, such as ketoconazole, abiraterone acetate, VN/124-1 (TOK-001) and TAK-700 in the clinic and in clinical development are highlighted.

TL;DR: The molting gland, or Y-organ (YO), is the primary site for ecdysteroid synthesis in decapod crustaceans and inactivation involves conversion of Ecdysteroids to polar metabolites and/or conjugates, which are eliminated in the urine and feces.

TL;DR: The peroxisome proliferator-activated receptor gamma (PPARγ) is a key regulator of adipogenesis and is medically important for its connections to obesity and the treatment of type II diabetes.

TL;DR: This review will highlight the evidence for androgen disrupting chemicals that act through interference with the androgen receptor, discussing specific compounds for which there is documented in vivo evidence for male reproductive tract perturbations.

TL;DR: The 24,25:25VD(3) ratio may have clinical utility as a marker for VD (3) catabolism and a predictor of serum 25VD( 3) response to VD(2) supplementation.

TL;DR: It is found that TBT induces adipogenesis, triglyceride storage and the expression of adipogenic marker genes in 3T3-L1 cells in a PPARγ-dependent manner and indicates that ligand stability is an important consideration in the design and interpretation of adipogenesis assays.

TL;DR: It is demonstrated that metformin promotes PR expression, which can be inhibited by overexpressed IGF-II in EC, and this effect is partially mediated through activating AMPK followed by inhibiting the overactivated mTOR pathway.

TL;DR: Substantial evidence demonstrates the mutagenicity of the estrogen metabolites and their ability to induce transformation of mouse and human breast epithelial cells, and tumors in laboratory animals.

TL;DR: Different sample preparation methods to extract estrogen-like compounds from bottled water are compared and the contamination of bottled water with endocrine disruptors is indicated to be a transnational phenomenon.

TL;DR: A review of human, animal, and cell culture studies showing that vitamin D affects muscle strength and function aims to explore the effects of vitamin D on skeletal muscle in each model system and to delineate potential cell signaling pathways affected by vitamin D.

TL;DR: It is found that there are subpockets involved in ligand binding that are considerably different in AKR1C3 relative to the closely related AKR2C1 or AKR3C2 isoforms, which can be used to further improve the binding affinity and selectivity of the currently available AKR 1C3 inhibitors.

TL;DR: A fast and sensitive LC-MS/MS method for the quantitative analysis of seven steroid hormones in 150 μl of human serum was developed and validated and applied for the serum steroid profiling of endometriosis patients.

TL;DR: Evidence is presented to show that in the case of CYP17 the attack of Fe(III)-O-O(-) on the target carbon is promoted by cytochrome b(5), which acts as a conformational regulator of CYp17 that provides a safety mechanism which ensures that during corticoid biosynthesis, which involves 17α-hydroxylation by CYP19, androgen formation is avoided.

TL;DR: Vitamin D intake was significantly predictive of serum 25(OHD) concentrations, and similarly to what was observed for the GC polymorphisms, the relative strength of the association was influenced by ancestry and season.

TL;DR: Past and recent studies dealing with steroid biosynthesis and metabolism in different molluscs species suggest the involvement of steroids in mollusc reproduction, but many questions remain to be answered.

TL;DR: R mediates non-genomic actions of AhR-ligands through the assembly of a CUL4B-based ubiquitin ligase complex and promotes the degradation of ERα and AR, revealing the roles of the ubiquit in system in sensing and biological response to environmental chemicals.

TL;DR: Xenoestrogens can alter endogenous estrogens' signaling and thereby disrupt normal signaling pathways, leading to malfunctions in many tissue types, and they must be carefully tested for activity and toxicity over wide dose ranges.

TL;DR: The results suggest that nuclear VDR status may be a prognostic marker in NSCLC and future large studies to replicate the findings are required as therapies targeting the vitamin D signaling pathway may be influenced by VDRstatus in the target lung cancer tissue.

TL;DR: In November, conservationists were celebrating the good news about pelicans, and the Potomac Conservancy issued a report on the State of the Nation’s River, which highlighted evidence that male smallmouth bass in the river all contained measureable levels of at least one EDC and that 80% of the male fish had developed female characteristics.

TL;DR: Two cases are presented, thyroid disrupting chemicals and anti-androgens chemicals, which illustrate how knowledge of the relationship between EDCs and adverse human health effects is strengthened and data gaps reduced when the authors integrate findings from animal and human studies.

TL;DR: The findings presented here provide additional evidence that BPA and the estrogenic drug ethinylestradiol disrupt prostate development in male mice at administered doses relevant to human exposures.

TL;DR: The results suggest that ERRγ plays an important role as a modulator of estrogen signaling in breast cancer cells, and is likely to stimulate ERE-mediated transcription with or without ERα.