R
Robert E. Rhoads
Researcher at Louisiana State University
Publications - 128
Citations - 10698
Robert E. Rhoads is an academic researcher from Louisiana State University. The author has contributed to research in topics: Messenger RNA & Protein biosynthesis. The author has an hindex of 56, co-authored 128 publications receiving 10438 citations. Previous affiliations of Robert E. Rhoads include Boehringer Ingelheim & LSU Health Sciences Center Shreveport.
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Journal ArticleDOI
A computer program for choosing optimal oligonucleotides for filter hybridization, sequencing and in vitro amplification of DNA
TL;DR: A method is presented for choosing optimal oligodeoxyribonucleotides as probes for filter hybridization, primer for sequencing, or primers for DNA amplification, based on a simple dynamic algorithm.
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Mapping of functional domains in eukaryotic protein synthesis initiation factor 4G (eIF4G) with picornaviral proteases. Implications for cap-dependent and cap-independent translational initiation
TL;DR: Results suggest that cleavage by picornaviral proteases at residues 479-486 separates eIF4G into two domains, one required for recruiting capped mRNAs and one for attaching mRNA to the ribosome and directing helicase activity.
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Enteroviral protease 2A cleaves dystrophin: Evidence of cytoskeletal disruption in an acquired cardiomyopathy
Cornel Badorff,Gil-Hwan Lee,Barry J. Lamphear,Maryann E. Martone,Kevin P. Campbell,Robert E. Rhoads,Kirk U. Knowlton +6 more
TL;DR: It is demonstrated here that purified Coxsackievirus protease 2A cleaves dystrophin in vitro as predicted by computer analysis, suggesting a molecular mechanism through which enteroviral infection contributes to the pathogenesis of acquired forms of dilated cardiomyopathy.
Journal ArticleDOI
Novel “anti-reverse” cap analogs with superior translational properties
Jacek Jemielity,Tolvert Fowler,Joanna Zuberek,Janusz Stepinski,Magdalena Lewdorowicz,Anna Niedzwiecka,Ryszard Stolarski,Edward Darzynkiewicz,Robert E. Rhoads +8 more
TL;DR: Seven new cap analogs modified in the C2' and C3' positions of m(7)Guo and in the number of phosphate residues are synthesized, indicating that modifications at C2', like those at C3', prevent reverse incorporation, and that tetra- and pentaphosphate cap analogues bind eIF4E and inhibit translation more strongly than their triphosphate counterparts.