Robert E. Vann

TL;DR: A selective and efficacious dual FAAH/MAGL inhibitor is described and it is shown that this agent exhibits broad activity in the tetrad test for CB1 agonism, causing analgesia, hypomotilty, and catalepsy, indicating that AEA and 2-AG signaling pathways interact to regulate specific behavioral processes in vivo, including those relevant to drug abuse.

TL;DR: Results show that α5(−/−) mice are less sensitive to the initial effects of nicotine in antinociception, locomotor activity, and hypothermia measures and that the α5 nAChR is involved in nicotine reward.

TL;DR: This study has generated several novel candidate genes for antipsychotic response and will require replication and functional validation, and provides all GWAS p-values for download.

TL;DR: CBD, when administered with THC at therapeutically relevant ratios, may ameliorate aversive effects often associated with initial use of THC alone, and this effect may be beneficial for therapeutic usage of a CBD:THC combination medication.

TL;DR: Inhalation exposure to a product containing JWH-018 penetrates into the brain and other organs and produces CB(1) receptor-mediated behavioral pharmacological effects in mice, undoubtedly contribute to public health risks of synthetic cannabinoids.