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Xiangning Chen
Researcher at Virginia Commonwealth University
Publications - 103
Citations - 6482
Xiangning Chen is an academic researcher from Virginia Commonwealth University. The author has contributed to research in topics: Single-nucleotide polymorphism & Nicotine. The author has an hindex of 41, co-authored 98 publications receiving 6107 citations. Previous affiliations of Xiangning Chen include University of Texas Southwestern Medical Center & Washington University in St. Louis.
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Journal ArticleDOI
Fluorescence Polarization in Homogeneous Nucleic Acid Analysis
TL;DR: This homogeneous DNA diagnostic method is shown to be highly sensitive and specific and is suitable for automated genotyping of large number of samples.
Journal ArticleDOI
Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity: a Meta-Analysis and Comparison with Lung Cancer and COPD
Nancy L. Saccone,Nancy L. Saccone,Robert Culverhouse,Tae-Hwi Schwantes-An,Dale S. Cannon,Xiangning Chen,Sven Cichon,Ina Giegling,Shizhong Han,Younghun Han,Kaisu Keskitalo-Vuokko,Xiangyang Kong,Maria Teresa Landi,Jennie Z. Ma,Susan E. Short,Susan E. Short,Sarah H. Stephens,Victoria L. Stevens,Lingwei Sun,Yufei Wang,Angela S. Wenzlaff,Steven H. Aggen,Naomi Breslau,Peter Broderick,Nilanjan Chatterjee,Jingchun Chen,Andrew C. Heath,Markku Heliövaara,Nicole R. Hoft,David J. Hunter,Majken K. Jensen,Nicholas G. Martin,Grant W. Montgomery,Tianhua Niu,Thomas J. Payne,Leena Peltonen,Michele L. Pergadia,John P. Rice,Richard Sherva,Margaret R. Spitz,Juzhong Sun,Jen C. Wang,Robert B. Weiss,William Wheeler,Stephanie H. Witt,Bao-Zhu Yang,Neil E. Caporaso,Marissa A. Ehringer,Tim Eisen,Susan M. Gapstur,Joel Gelernter,Richard S. Houlston,Jaakko Kaprio,Jaakko Kaprio,Kenneth S. Kendler,Peter Kraft,Mark Leppert,Ming D. Li,Pamela A. F. Madden,Markus M. Nöthen,Sreekumar G. Pillai,Marcella Rietschel,Dan Rujescu,Ann G. Schwartz,Christopher I. Amos,Laura J. Bierut +65 more
TL;DR: This study provides strong evidence that multiple statistically distinct loci in this region affect smoking behavior, and is the first report of association between rs588765 (and correlates) and smoking that achieves genome-wide significance.
Journal ArticleDOI
Single nucleotide polymorphism genotyping: biochemistry, protocol, cost and throughput.
TL;DR: A general description of SNP typing protocols and a summary of current methods for each step of the protocol are pointed out, pointing out the unique features and weaknesses of these techniques as well as comparing the cost and throughput structures of the technologies.
Journal ArticleDOI
Detection of single nucleotide polymorphisms.
Pui-Yan Kwok,Xiangning Chen +1 more
TL;DR: The SNP detection technologies have evolved from labor intensive, time consuming, and expensive processes to some of the most highly automated, efficient, and relatively inexpensive methods as discussed by the authors, and robust strategies are found in both SNP discovery and genotyping areas.
Journal ArticleDOI
SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive
Sergiy Libert,Kelli B. Pointer,Eric L. Bell,Abhirup Das,Dena E. Cohen,Dena E. Cohen,John M. Asara,Karen Kapur,Sven Bergmann,Martin Preisig,Takeshi Otowa,Kenneth S. Kendler,Xiangning Chen,John M. Hettema,Edwin J. C. G. van den Oord,Justin P. Rubio,Leonard Guarente +16 more
TL;DR: Treating animals with MAO-A inhibitors or selective serotonin reuptake inhibitors (SSRIs) normalized anxiety differences between wild-type and mutant animals, indicating that SIRT1 mediates levels of anxiety, and this regulation may be adaptive in a changing environment of food availability.