Karolina A. Aberg

TL;DR: In this cohort study, cumulative childhood trauma was associated with higher rates of adult psychiatric disorders and poorer functional outcomes even after adjusting for a broad range of other childhood risk factors for these outcomes.

TL;DR: This methylome-wide association study of schizophrenia is one of the first MWASs of disease with a large sample size using a technology that provides good coverage of methylation sites across the genome and demonstratedone of the unique features ofmethylation studies that can capture signatures of environmental insults in peripheral tissues.

TL;DR: It is shown that human QKI mRNA levels can account for a high proportion of normal interindividual mRNA expression variation (and covariation) of six oligodendrocyte-related genes in 55 human brain autopsy samples from individuals without psychiatric diagnoses, and hypothesize that previously observed decreased activity of myelin- related genes in schizophrenia might be caused by disturbed QKI splicing.

TL;DR: The potential of GWAS to discover genes and pathways that potentially mediate adverse effects of antipsychotic medication is shown, with the top finding indicated that a SNP in Meis homeobox 2 (MEIS2) mediated the effects of risperidone on hip circumference.

TL;DR: A meta-analysis of genome-wide association studies involving 1,085,772 single-nucleotide polymorphisms (SNPs) and 6 databases that showed significant informativeness for SCZ replicated novel SCZ disease genes and pathogenic pathways.