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Robert F Lodato
Researcher at University of Texas Health Science Center at Houston
Publications - 38
Citations - 2847
Robert F Lodato is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Mechanical ventilation & Shock (circulatory). The author has an hindex of 21, co-authored 38 publications receiving 2756 citations. Previous affiliations of Robert F Lodato include Veterans Health Administration & Johns Hopkins University.
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Journal ArticleDOI
NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide.
Robert G. Kilbourn,Steven S. Gross,Amal Jubran,James Adams,Owen W. Griffith,Roberto Levi,Robert F Lodato +6 more
TL;DR: It is suggested that excessive nitric oxide production mediates the hypotensive effect of TNF, a potent vasodilator initially characterized as endothelium-derived relaxing factor.
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The pattern of breathing during successful and unsuccessful trials of weaning from mechanical ventilation.
Martin J. Tobin,W. Perez,S. M. Guenther,B J Semmes,M. J. Mador,Steven J. Allen,Robert F Lodato,David R. Dantzker +7 more
TL;DR: The pattern of breathing in patients being weaned from mechanical ventilation was prospectively examined: one group underwent a successful weaning trial and were extubated, whereas another group developed respiratory failure and required the reinstitution of mechanical ventilation.
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Variability of resting respiratory drive and timing in healthy subjects
TL;DR: Examination of breath-to-breath variability in breathing pattern over a 15-min period in 65 subjects revealed large coefficients of variation, indicating the need to base calculations on a relatively large number of breaths.
Journal ArticleDOI
Multicenter, double-blind, placebo-controlled study of the use of filgrastim in patients hospitalized with pneumonia and severe sepsis.
Richard K. Root,Robert F Lodato,Ward Patrick,John F. Cade,Nick Fotheringham,Steven Milwee,Jean Louis Vincent,Antoni Torres,Jordi Rello,Steve Nelson,Steve Nelson +10 more
TL;DR: The addition of filgrastim to the antibiotic and supportive care treatment of patients with pneumonia complicated by severe sepsis appeared to be safe, but not efficacious in reducing mortality rates or complications from this infection.
Journal ArticleDOI
Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002).
Jan Bakker,Robert Grover,A McLuckie,Laurent Holzapfel,Jan Andersson,Robert F Lodato,David Watson,Steven H. Grossman,Jill Donaldson,Jukka Takala,Jukka Takala +10 more
TL;DR: Treatment with the nitric oxide synthase inhibitor 546C88 promoted the resolution of shock in patients with severe sepsis and was associated with an acceptable overall safety profile.