Robert Golden

TL;DR: It is biologically implausible that parabens could increase the risk of any estrogen-mediated endpoint, including effects on the male reproductive tract or breast cancer, and a comparative approach involving both dose and potency is used to assess whether in utero or adult exposure to paraben might be associated with adverse effects mediated via an estrogen-modulating mode of action.

TL;DR: Biological plausibility alone is an insufficient basis for concluding that environmental endocrine modulators have adversely affected humans, and it appears unlikely that in utero exposure to usual levels of environmental estrogenic substances, from whatever source, would be sufficient to produce many of the effects.

TL;DR: It is concluded that a formaldehyde indoor air limit of 0.1 ppm should protect even particularly susceptible individuals from both irritation effects and any potential cancer hazard.

TL;DR: The weight of the scientific evidence concerning chloroform-induced tumors in rodents is consistent with and supports a cancer risk assessment methodology based on mode of action as the basis for establishing regulatory standards for this compound.

TL;DR: The dramatic differences between rodents and humans in sensitivity to PCB-mediated induction of CYP1A1 suggests that even occupational exposures to PCBs have never resulted in PCB body burdens approaching the levels required to initiate the sequence of events involved in the promotion of liver tumors in rodents.