R
Robert H. Barker
Researcher at Genzyme
Publications - 43
Citations - 1639
Robert H. Barker is an academic researcher from Genzyme. The author has contributed to research in topics: Hybridization probe & Plasmodium falciparum. The author has an hindex of 23, co-authored 41 publications receiving 1569 citations. Previous affiliations of Robert H. Barker include Broad Institute & Harvard University.
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Journal ArticleDOI
A simple method to detect Plasmodium falciparum directly from blood samples using the polymerase chain reaction.
Robert H. Barker,Trairat Banchongaksorn,Jeanne M. Courval,Wannapa Suwonkerd,Kamolwan Rimwungtragoon,Dyann F. Wirth +5 more
TL;DR: A simple method of treating blood samples for PCR that permits detection of less than than 10 parasites in a 20-microliters sample, and minimizes the effects of PCR inhibitors generally found in blood, which is useful in other diagnostic assays.
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A simple method for diagnosing M. tuberculosis infection in clinical samples using PCR.
TL;DR: The results suggest that the PCR method may provide a sensitive alternative to conventional species-specific diagnostic methods, and that non-isotopic labelling can be used to detect hybridization in this assay.
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Specific DNA probe for the diagnosis of Plasmodium falciparum malaria.
TL;DR: A simple procedure was developed for spotting lysed blood from infected patients directly onto nitrocellulose paper and identifying the malaria species on the basis of hybridization of parasite DNA with a species-specific probe.
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Novel Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model
Michael Booker,Cecilia M. Bastos,Martin Kramer,Robert H. Barker,Renato Skerlj,Amar Bir Singh Sidhu,Xiaoyi Deng,Cassandra Celatka,Joseph F. Cortese,Jose E. Guerrero Bravo,Keila N. Crespo Llado,Adelfa E. Serrano,Iñigo Angulo-Barturen,María Belén Jiménez-Díaz,Sara Viera,Helen Garuti,Sergio Wittlin,Sergio Wittlin,Petros Papastogiannidis,Petros Papastogiannidis,Jing-wen Lin,Chris J. Janse,Shahid M. Khan,Manoj T. Duraisingh,Bradley I. Coleman,Elizabeth J. Goldsmith,Margaret A. Phillips,Benito Munoz,Dyann F. Wirth,Jeffrey D. Klinger,Roger C. Wiegand,Edmund Sybertz +31 more
TL;DR: A series of N-alkyl-5-(1H-benzimidazol-1-yl)thiophene-2-carboxamides with low nanomolar in vitro potency against DHODH demonstrated good tolerability and oral exposure in the mouse, and ED50 values in the 4-day murine P. berghei efficacy model resulted in sterile cure.
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GT160-246, a toxin binding polymer for treatment of Clostridium difficile colitis.
Caroline B. Kurtz,E. Pat Cannon,Alex Brezzani,Mary Pitruzzello,Carol Dinardo,Emilie Rinard,David W. K. Acheson,Richard Fitzpatrick,Pamela Kelly,Keith K. Shackett,Andrew T. Papoulis,Philip J. Goddard,Robert H. Barker,Gerard P. Palace,Jeffrey D. Klinger +14 more
TL;DR: GT160-246 showed no antimicrobial activity in tests with a panel of 16 aerobic bacteria and yeast and 22 anaerobic bacteria and did not interfere with the in vitro activities of most antibiotics, and offers a novel, nonantimicrobial treatment of C. difficile disease in humans.