S
Shahid M. Khan
Researcher at Leiden University Medical Center
Publications - 115
Citations - 6932
Shahid M. Khan is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Plasmodium berghei & Plasmodium falciparum. The author has an hindex of 43, co-authored 112 publications receiving 5905 citations. Previous affiliations of Shahid M. Khan include Jikei University School of Medicine & Loyola University Medical Center.
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Journal ArticleDOI
Regulation of sexual development of Plasmodium by translational repression.
Gunnar R. Mair,Joanna A. M. Braks,Lindsey S. Garver,Joop Wiegant,Neil Hall,Roeland W. Dirks,Shahid M. Khan,George Dimopoulos,Chris J. Janse,Andrew P. Waters +9 more
TL;DR: Translational repression and mRNA turnover were shown to influence stage-specific gene expression in the protozoan Plasmodium and the DDX6-class RNA helicase, DOZI, is found in a complex with mRNA species in cytoplasmic bodies of female, blood-stage gametocytes.
Journal ArticleDOI
Proteome Analysis of Separated Male and Female Gametocytes Reveals Novel Sex-Specific Plasmodium Biology
Shahid M. Khan,Blandine Franke-Fayard,Gunnar R. Mair,Edwin Lasonder,Edwin Lasonder,Chris J. Janse,Matthias Mann,Andrew P. Waters +7 more
TL;DR: The male gametocyte has the most distinct proteome, containing many proteins involved in flagellar-based motility and rapid genome replication, and new sex-specific regulatory pathways were defined.
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Analysis of infected blood cell images using morphological operators
TL;DR: A morphological approach to cell image segmentation, that is, more accurate than the classical watershed-based algorithm, is introduced for detecting and classifying malaria parasites in images of Giemsa stained blood slides.
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A comprehensive evaluation of rodent malaria parasite genomes and gene expression
Thomas D. Otto,Ulrike Böhme,Andrew P. Jackson,Martin Hunt,Blandine Franke-Fayard,Wieteke A. M. Hoeijmakers,Agnieszka A. Religa,Lauren Robertson,Mandy Sanders,Solabomi A. Ogun,Deirdre Cunningham,Annette Erhart,Oliver Billker,Shahid M. Khan,Hendrik G. Stunnenberg,Jean Langhorne,Anthony A. Holder,Andrew P. Waters,Chris I. Newbold,Arnab Pain,Matthew Berriman,Chris J. Janse +21 more
TL;DR: The greatly improved genome assemblies of PbA and PcAS, newly sequenced the virulent parasite P. yoelii YM genome, sequenced additional RMP isolates/lines and have characterized genotypic diversity within RMP species.
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Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging.
Ivo H J Ploemen,Miguel Prudêncio,Bruno Douradinha,Jai Ramesar,Jannik Fonager,Geert-Jan van Gemert,Adrian J. F. Luty,Cornelus C. Hermsen,Robert W. Sauerwein,Fernanda Baptista,Maria M. Mota,Andrew P. Waters,Ivo Que,Clemens W.G.M. Löwik,Shahid M. Khan,Chris J. Janse,Blandine Franke-Fayard +16 more
TL;DR: The use of a transgenic P. berghei parasite expressing the bioluminescent reporter protein luciferase to visualize and quantify parasite development in liver cells both in culture and in live mice using real-time luminescence imaging opens up new possibilities for research on Plasmodium liver infections and for validating the effect of drugs and vaccines on the liver stage.