Robert J. Gorelick

TL;DR: The persistent immune activation associated with HIV infection is not impacted by the anti-inflammatory effects of mesalamine, at least under the conditions studied.

TL;DR: The effects of hypermutation on the HIV-1 recombination rate and its contribution to genetic variation through recombination to generate progeny genomes containing portions of hypermutated genomes without lethal mutations are determined.

TL;DR: This pioneering study reports here the direct and real-time analysis on such properties of proteolytic intermediate NCp15 and mature NCp7 using DNA origami and expects that this pioneering study will strengthen the understanding on the chaperone activity of HIV-1 proteins which in turn will be helpful for the drug design based on G-quadruplex and also for the development of drugs against AIDS.

TL;DR: It is suggested that specific basic residues enhance these interactions, resulting in optimal NA chaperone activity, and HIV-1 infectivity in cells is correlated most strongly with NC’s NA annealing capabilities as well as its ability to intercalate the DNA duplex.

TL;DR: Multiple previously unannotated structural elements in the HIV-1 genome likely to function in translation, splicing and other replication cycle processes are identified; these are compelling targets for future functional analyses.