Robert L. Dwyer

TL;DR: This journal issue includes papers that describe recent advances with regard to the development of the biotic ligand model and represents a distinct milestone in the ongoing evolution of the BLM approach and, more generally, of approaches to performing ecological assessments for metals in aquatic systems.

TL;DR: In this paper, a basic framework for the ecological weight-of-evidence (WOE) process for sediment assessment is presented, which clearly defines its essential elements and will improve the certainty of conclusions about whether or not impairment exists due to sediment contamination, and, if so, which stressors and biological species (or ecological responses) are of greatest concern.

TL;DR: The present review discusses the history of scientific understanding of metal bioavailability and the development and application of models to incorporate this knowledge into regulatory practice, and the evolution of ambient water quality criteria over the last 50 yr.

TL;DR: The current framework and research questions identified in a roadmap are described and a summary of key questions along with preliminary recommendations to address them as well as open questions that require additional research efforts are concluded.

TL;DR: The Metal Mixture Modeling Evaluation project and workshop achieved 3 important objectives related to modeling and interpretation of biological effects of metal mixtures: 1) bioavailability models calibrated for single-metal exposures can be integrated to assess mixture scenarios; 2) the available modeling approaches perform consistently well for various metal combinations, organisms, and endpoints; and several technical advancements have been identified.