G
Geppino Falco
Researcher at University of Naples Federico II
Publications - 61
Citations - 3362
Geppino Falco is an academic researcher from University of Naples Federico II. The author has contributed to research in topics: Embryonic stem cell & Gene. The author has an hindex of 23, co-authored 54 publications receiving 2914 citations. Previous affiliations of Geppino Falco include University of Sannio & National Institutes of Health.
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Journal ArticleDOI
Age-associated alteration of gene expression patterns in mouse oocytes
Toshio Hamatani,Geppino Falco,Mark G. Carter,Hidenori Akutsu,Carole A. Stagg,Alexei A. Sharov,Dawood B. Dudekula,Vincent VanBuren,Minoru S.H. Ko +8 more
TL;DR: A group of new oocyte-specific genes, members of the human NACHT, leucine-rich repeat and PYD-containing (NALP) gene family are identified and characterized, suggesting the existence of additional mechanisms for aging.
Journal ArticleDOI
AGEMAP: a gene expression database for aging in mice.
Jacob M. Zahn,Suresh Poosala,Art B. Owen,Donald K. Ingram,Ana Lustig,Arnell Carter,Ashani T. Weeraratna,Dennis D. Taub,Myriam Gorospe,Krystyna Mazan-Mamczarz,Edward G. Lakatta,Kenneth R. Boheler,Xiangru Xu,Mark P. Mattson,Geppino Falco,Minoru S.H. Ko,David Schlessinger,Jeffrey Firman,Sarah K. Kummerfeld,William H. Wood,Alan B. Zonderman,Stuart K. Kim,Kevin G. Becker +22 more
TL;DR: The AGEMAP (Atlas of Gene Expression in Mouse Aging Project) gene expression database is presented, which is a resource that catalogs changes in gene expression as a function of age in mice and finds great heterogeneity in the amount of transcriptional changes with age in different tissues.
Journal ArticleDOI
Zscan4 regulates telomere elongation and genomic stability in ES cells
Michal Zalzman,Geppino Falco,Lioudmila V. Sharova,Akira Nishiyama,Marshall Thomas,Sung Lim Lee,Carole A. Stagg,Hien G. Hoang,Hsih Te Yang,Fred E. Indig,Robert P. Wersto,Minoru S.H. Ko +11 more
TL;DR: Zscan4 knockdown shortens telomeres, increases karyotype abnormalities and spontaneous sister chromatid exchange, and slows down cell proliferation until reaching crisis by passage eight, which shows a unique mode of genome maintenance in ES cells.
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Zscan4: a novel gene expressed exclusively in late 2-cell embryos and embryonic stem cells
Geppino Falco,Sung Lim Lee,Ilaria Stanghellini,Uwem C. Bassey,Toshio Hamatani,Minoru S.H. Ko +5 more
TL;DR: Zscan4 seems to be essential for preimplantation development, as reduction of Zscan4 transcript levels by siRNAs delays the progression from the 2-cell to the 4-cell stage and produces blastocysts that fail to implant or proliferate in blastocyst outgrowth culture.
Journal ArticleDOI
Identification and functional outcome of mRNAs associated with RNA-binding protein TIA-1.
Isabel López de Silanes,Stefanie Galbán,Jennifer L. Martindale,Xiaoling Yang,Krystyna Mazan-Mamczarz,Fred E. Indig,Geppino Falco,Ming Zhan,Myriam Gorospe +8 more
TL;DR: A signature motif present in mRNAs that associate with TIA-1 is reported and provided support to the notion that Tia-1 represses the translation of target transcripts.