R
Roberta Donadelli
Researcher at Mario Negri Institute for Pharmacological Research
Publications - 54
Citations - 5009
Roberta Donadelli is an academic researcher from Mario Negri Institute for Pharmacological Research. The author has contributed to research in topics: Atypical hemolytic uremic syndrome & Complement system. The author has an hindex of 26, co-authored 48 publications receiving 4543 citations. Previous affiliations of Roberta Donadelli include Scripps Research Institute.
Papers
More filters
Journal ArticleDOI
Relative Role of Genetic Complement Abnormalities in Sporadic and Familial aHUS and Their Impact on Clinical Phenotype
Marina Noris,Jessica Caprioli,Elena Bresin,Chiara Mossali,Gaia Pianetti,Sara Gamba,Erica Daina,Chiara Fenili,Federica Castelletti,Annalisa Sorosina,Rossella Piras,Roberta Donadelli,Ramona Maranta,Irene van der Meer,Edward M. Conway,Peter F. Zipfel,Timothy H.J. Goodship,Giuseppe Remuzzi +17 more
TL;DR: Results underline the need of genetic screening for all susceptibility factors as part of clinical management of aHUS and for identification of patients who could safely benefit from kidney transplant.
Journal ArticleDOI
Nitric Oxide Synthesis by Cultured Endothelial Cells Is Modulated by Flow Conditions
Marina Noris,Marina Morigi,Roberta Donadelli,Sistiana Aiello,Marco Foppolo,Marta Todeschini,Silvia Orisio,Giuseppe Remuzzi,Andrea Remuzzi +8 more
TL;DR: Results indicate that local blood flow conditions modulate the production of vasoactive substances by endothelial cells, which may affect vascular cell functions such as nonthrombogenicity, regulation of blood flow, and vascular tone.
Journal ArticleDOI
Leukocyte-endothelial interaction is augmented by high glucose concentrations and hyperglycemia in a NF-kB-dependent fashion.
Marina Morigi,Stefania Angioletti,Barbara Imberti,Roberta Donadelli,Gianluca Micheletti,Marina Figliuzzi,Andrea Remuzzi,Carla Zoja,Giuseppe Remuzzi +8 more
TL;DR: Data indicate that high glucose concentration and hyperglycemia promote leukocyte adhesion to the endothelium through upregulation of cell surface expression of adhesive proteins, possibly depending on NF-kB activation.
Journal ArticleDOI
Protein overload stimulates RANTES production by proximal tubular cells depending on NF-kB activation
Carla Zoja,Roberta Donadelli,Stella Colleoni,Marina Figliuzzi,Samantha Bonazzola,Marina Morigi,Giuseppe Remuzzi +6 more
TL;DR: Given its chemotactic activity, RANTES released into the interstitium might promote inflammatory cell recruitment and contribute to interstitial inflammation and renal disease progression.
Journal ArticleDOI
Dynamics of complement activation in aHUS and how to monitor eculizumab therapy
Marina Noris,Miriam Galbusera,Sara Gastoldi,Paolo Macor,Federica Banterla,Elena Bresin,Claudio Tripodo,Serena Bettoni,Roberta Donadelli,Elisabetta Valoti,Francesco Tedesco,Alessandro Amore,Rosanna Coppo,Piero Ruggenenti,Eliana Gotti,Giuseppe Remuzzi +15 more
TL;DR: Results point to efficient complement inhibition on endothelium for aHUS treatment, including C5b-9 endothelial deposits, which might help monitor eculizumab effectiveness, avoid drug overexposure, and save money considering the extremely high cost of the drug.