Roberta Verta

TL;DR: Bruton's tyrosine kinase is highly expressed in monocytes and macrophages and regulates NF‐κB and NLRP3 inflammasome activity; both propagate metabolic inflammation in diet‐induced obesity.

TL;DR: Overall, the data indicates that chronic exposure to dietary AGEs lead to a significant unbalance in incretins axis, markers of metabolic inflammation, and a reshape of both the intestinal microbiota and plasma protein glycosylation profile, suggesting intriguing pathological mechanisms underlying A GEs-induced metabolic derangements.

TL;DR: The data suggest that the JAK2-STAT2 pathway may represent a novel candidate for the treatment of diet-related metabolic derangements, with the potential for EMA- and FDA-approved JAK inhibitors to be repurposed for the Treatment of type 2 diabetes and/or its complications.

TL;DR: An up‐to‐date review of the pathophysiological role of histamine in the kidney is provided, addressing the questions of the redundancy of H1 and H2 receptors in renal haemodynamics, the complementary role of H 1 and H4 receptors in kidneys filtration and reabsorption, and the dichotomy between local and neuronal H1and H3 receptors.

TL;DR: The evidence collected on the role of histamine in kidney function together with its well-known pleiotropic action suggest that this amine may act simultaneously on glomerular hyperfiltration, tubular inflammation, fibrosis development and tubular hypertrophy.