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Roberto Bizzotto
Researcher at National Research Council
Publications - 20
Citations - 681
Roberto Bizzotto is an academic researcher from National Research Council. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 8, co-authored 17 publications receiving 438 citations.
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Journal ArticleDOI
Shift to Fatty Substrate Utilization in Response to Sodium-Glucose Cotransporter 2 Inhibition in Subjects Without Diabetes and Patients With Type 2 Diabetes.
Ele Ferrannini,Simona Baldi,Silvia Frascerra,Brenno Astiarraga,Tim Heise,Roberto Bizzotto,Andrea Mari,Thomas R. Pieber,Elza Muscelli +8 more
TL;DR: It is concluded that by shunting substantial amounts of carbohydrate into urine, SGLT2-mediated glycosuria results in a progressive shift in fuel utilization toward fatty substrates.
Journal ArticleDOI
Incretin and islet hormone responses to meals of increasing size in healthy subjects.
TL;DR: Mixed lunch meals of increasing size elicit a caloric-dependent insulin response due to increased β-cell secretion achieved by increased GIP and GLP-1 levels, resulting in a postpeak suppression of glucose below baseline.
Journal ArticleDOI
Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study
Agata Wesolowska-Andersen,Caroline Brorsson,Roberto Bizzotto,Andrea Mari,Andrea Tura,Robert W. Koivula,Anubha Mahajan,Ana Viñuela,Juan Fernandez Tajes,Sapna Sharma,Mark Haid,Cornelia Prehn,Anna Artati,Mun-Gwan Hong,PB Musholt,Azra Kurbasic,Federico De Masi,K. Tsirigos,Helle Krogh Pedersen,Valborg Gudmundsdottir,Cecilia Engel Thomas,Karina Banasik,Angus G. Jones,Gwen Kennedy,Jimmy D. Bell,Louise Thomas,G Frost,Henrik Thomsen,Kristine H. Allin,T. Hansen,Henrik Vestergaard,Torben Hansen,Femke Rutters,Petra J. M. Elders,L. t’Hart,Amélie Bonnefond,Mickaël Canouil,Soren Brage,Tarja Kokkola,Alison Heggie,Donna McEvoy,Andrew T. Hattersley,Timothy J. McDonald,Harriet Teare,Martin Ridderstråle,Mark Walker,I.M. Forgie,Giuseppe N. Giordano,Philippe Froguel,Imre Pavo,Hartmut Ruetten,Oluf Pedersen,Emmanouil T. Dermitzakis,Paul W. Franks,Jochen M. Schwenk,Jerzy Adamski,E W Pearson,Mark I. McCarthy,Søren Brunak +58 more
TL;DR: In this article , the authors apply a soft-clustering (archetype) method to characterize newly diagnosed Type 2 diabetes (T2D) based on 32 clinical variables and investigate the associations with glycemic deterioration, genetic risk scores, circulating omics biomarkers, and phenotypic stability over 36 months.
Journal ArticleDOI
Mixed meal ingestion diminishes glucose excursion in comparison with glucose ingestion via several adaptive mechanisms in people with and without type 2 diabetes.
TL;DR: To study the integrative impact of macronutrients on postprandial glycaemia, β‐cell function, glucagon and incretin hormones in humans, a large number of animals have been studied.
Journal ArticleDOI
Inhibition of sweet chemosensory receptors alters insulin responses during glucose ingestion in healthy adults: a randomized crossover interventional study
Elnaz Karimian Azari,Kathleen R. Smith,Fanchao Yi,Timothy F. Osborne,Roberto Bizzotto,Andrea Mari,Richard E. Pratley,Richard E. Pratley,George Kyriazis,George Kyriazis +9 more
TL;DR: The pharmacologic inhibition of STRs in the gastrointestinal tract alters insulin responses during an oral glucose challenge in lean healthy participants, and the effects of lactisole on the OGTT are eliminated.