Roy Kishony

TL;DR: To explore how the problem of antibiotic resistance might best be addressed, a group of 30 scientists from academia and industry gathered at the Banbury Conference Centre in Cold Spring Harbor, New York, USA, from 16 to 18 May 2011.

TL;DR: A selection device, the 'morbidostat', that continuously monitors bacterial growth and dynamically regulates drug concentrations, such that the evolving population is constantly challenged, shows that parallel populations evolved similar mutations and acquired them in a similar order.

TL;DR: It is found that the ensuing epistatic interaction network could be organized hierarchically into function-enriched modules that interact with each other 'monochromatically' (i.e., with purely aggravating or purely buffering epistatic links) and provides a new definition of biological modularity, which emphasizes interactions between, rather than within, functional modules.

TL;DR: A protocol for rapid and inexpensive preparation of hundreds of multiplexed genomic libraries for Illumina sequencing by carrying out the Nextera tagmentation reaction in small volumes, replacing costly reagents with cheaper equivalents, and omitting unnecessary steps is presented.

TL;DR: It is demonstrated that wild-type persistence is suited for environments in which antibiotic stress is a rare event, and that clonal bacterial populations may use persister cells, whose slow division rate under growth conditions leads to lower population fitness, as an “insurance policy” against antibiotic encounters.