R
Rosa Sirianni
Researcher at University of Calabria
Publications - 63
Citations - 2995
Rosa Sirianni is an academic researcher from University of Calabria. The author has contributed to research in topics: Estrogen receptor & Aromatase. The author has an hindex of 28, co-authored 57 publications receiving 2544 citations. Previous affiliations of Rosa Sirianni include University of Texas Southwestern Medical Center.
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Journal ArticleDOI
27-Hydroxycholesterol Promotes Cell-Autonomous, ER-Positive Breast Cancer Growth
Qian Wu,Tomonori Ishikawa,Rosa Sirianni,Hao Tang,Jeffrey G. McDonald,Ivan S. Yuhanna,Bonne M. Thompson,Luc Girard,Chieko Mineo,Rolf A. Brekken,Michihisa Umetani,David M. Euhus,Yang Xie,Philip W. Shaul +13 more
TL;DR: It is reported that the cholesterol metabolite 27-hydroxycholesterol (27HC) stimulates MCF-7 cell xenograft growth in mice, and in ER+ breast cancer patients, 27HC content in normal breast tissue is increased compared to that in cancer-free controls, and tumor 27 HC content is further elevated.
Journal ArticleDOI
Role of estrogen receptors and g protein-coupled estrogen receptor in regulation of hypothalamus-pituitary-testis axis and spermatogenesis.
TL;DR: The current knowledge concerning the role of estrogen/estrogen receptors molecular pathways in regulating GnRH, follicle-stimulating hormone, and luteinizing hormone release at the hypothalamic and pituitary levels in males as well as in controlling specific testicular functions such as spermatogenesis is summarized.
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Progress to Improve Oral Bioavailability and Beneficial Effects of Resveratrol
Adele Chimento,Francesca De Amicis,Rosa Sirianni,Maria Stefania Sinicropi,Francesco Puoci,Ivan Casaburi,Carmela Saturnino,Vincenzo Pezzi +7 more
TL;DR: The strategies used to improve pharmacokinetic characteristics and then beneficial effects of RSV are described and the biological results obtained on several synthetic derivatives containing different substituents, such as methoxylic, hydroxylic groups, or halogens on the RSV aromatic rings, will be described.
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The novel estrogen receptor, G protein-coupled receptor 30, mediates the proliferative effects induced by 17β-estradiol on mouse spermatogonial GC-1 cell line
Rosa Sirianni,Adele Chimento,Carmen Ruggiero,Arianna De Luca,Rosamaria Lappano,Sebastiano Andò,Marcello Maggiolini,Vincenzo Pezzi +7 more
TL;DR: Results indicate for the first time that estrogens, through a cross talk between GPR30 and ERalpha, activate the rapid EGFR/ERK/fos pathway, which in turn stimulate mouse GC-1 cell proliferation.
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Oleuropein and hydroxytyrosol inhibit MCF‐7 breast cancer cell proliferation interfering with ERK1/2 activation
Rosa Sirianni,Adele Chimento,Arianna De Luca,Ivan Casaburi,Pietro Rizza,Arianna Onofrio,Domenico Iacopetta,Francesco Puoci,Sebastiano Andò,Marcello Maggiolini,Vincenzo Pezzi +10 more
TL;DR: It is demonstrated that HT and OL can have a chemo-preventive role in breast cancer cell proliferation through the inhibition of estrogen-dependent rapid signals involved in uncontrolled tumor cell growth.