Journal ArticleDOI
Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level.
Carmen Quintana,S. Bellefqih,J.Y. Laval,Jean-Luc Guerquin-Kern,T.D. Wu,J. Avila,I. Ferrer,Rocío Arranz,Cristina Patiño +8 more
TLDR
These findings provide new arguments to support the hypothesis of a dysfunction of Ft (with eventual degradation to Hm) in AD resulting in an increase of toxic brain ferrous ions that may contribute to the production of free radicals that induce both cellular oxidative stress and aged-related myelin breakdown associated with cognitive decline and AD.About:
This article is published in Journal of Structural Biology.The article was published on 2006-01-01. It has received 278 citations till now. The article focuses on the topics: Ferritin & Cognitive decline.read more
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Nanomaterials and nanoparticles: Sources and toxicity
TL;DR: A review of the toxicity of nanoparticles is presented in this paper, with the goal of informing public health concerns related to nanoscience while raising awareness of nanomaterials toxicity among scientists and manufacturers handling them.
Journal ArticleDOI
Nanomaterials and nanoparticles: Sources and toxicity
TL;DR: This review reveals the result of life’s long history of evolution in the presence of nanoparticles, and how the human body has adapted to defend itself against nanoparticulate intruders, while raising awareness of nanomaterials’ toxicity among scientists and manufacturers handling them.
Journal ArticleDOI
Magnetite pollution nanoparticles in the human brain.
Barbara A. Maher,Imad A. M. Ahmed,Vassil Karloukovski,Donald A. MacLaren,Penelope G. Foulds,David Allsop,David M. A. Mann,Ricardo Torres-Jardón,Lilian Calderón-Garcidueñas +8 more
TL;DR: Kirschvink et al. as discussed by the authors used magnetic analyses and electron microscopy to identify the abundant presence in the brain of magnetite nanoparticles that are consistent with high-temperature formation, suggesting, therefore, an external, not internal, source.
Journal ArticleDOI
Metals in Alzheimer's and Parkinson's Diseases
TL;DR: There has been steadily growing interest in the participation of metal ions in neurobiological processes, such as the regulation of synaptic transmission, and increasingly sophisticated medicinal chemistry approaches, which correct these metal abnormalities without causing systemic disturbance of these essential minerals, show promise of being disease-modifying.
Journal ArticleDOI
In Situ Imaging of Metals in Cells and Tissues
TL;DR: The aim of this review is to provide an overview of the most recent achievements in trace metal imaging while at the same time also offering a historical perspective of this rapidly evolving research field.
References
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Journal ArticleDOI
Oxidative stress hypothesis in alzheimer's disease
TL;DR: Supporting indirect evidence comes from a variety of in vitro studies showing that free radicals are capable of mediating neuron degeneration and death, suggesting that therapeutic efforts aimed at removal of ROS or prevention of their formation may be beneficial in AD.
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Iron, brain ageing and neurodegenerative disorders
TL;DR: By studying the accumulation and cellular distribution of iron during ageing, this work should be able to increase the understanding of these neurodegenerative disorders and develop new therapeutic strategies.
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Iron accumulation in Alzheimer disease is a source of redox-generated free radicals.
TL;DR: It is found, using a modified histochemical technique that relies on the formation of mixed valence iron complexes, that redox-active iron is associated with the senile plaques and neurofibrillary tangles-the pathological hallmark lesions of Alzheimer disease.
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Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer’s disease
TL;DR: A hypothetical model of Alzheimer's disease as a uniquely human brain disorder rooted in its exceptional process of myelination is presented, offering a framework that explains the anatomical distribution and progressive course of AD pathology, some of the failures of promising therapeutic interventions, and suggests further testable hypotheses as well as novel approaches for intervention efforts.
Journal ArticleDOI
In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: a central role for bound transition metals.
Lawrence M. Sayre,George Perry,Peggy L.R. Harris,Yahu A. Liu,Kathryn A. Schubert,Mark A. Smith +5 more
TL;DR: It is shown that neurofibrillary tangles and senile plaques are major sites for catalytic redox reactivity and may thereby exert prooxidant or possibly antioxidant activities, depending on the balance among cellular reductants and oxidants in the local microenvironment.