R
Rocio Rodriguez-Juarez
Researcher at University of Lethbridge
Publications - 31
Citations - 1293
Rocio Rodriguez-Juarez is an academic researcher from University of Lethbridge. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 16, co-authored 31 publications receiving 1143 citations.
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Journal ArticleDOI
Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo.
Igor Koturbash,Alex Boyko,Rocio Rodriguez-Juarez,Robert J. McDonald,Volodymyr Tryndyak,Igor Kovalchuk,Igor P. Pogribny,Olga Kovalchuk +7 more
TL;DR: This study is the first to report conclusive evidence of the long-term persistence of bystander effects in radiation carcinogenesis target organ (spleen) upon localized distant exposure using the doses comparable with those used for clinical brain tumor treatments.
Journal ArticleDOI
Induction of microRNAome deregulation in rat liver by long-term tamoxifen exposure.
Igor P. Pogribny,Volodymyr Tryndyak,Alex Boyko,Rocio Rodriguez-Juarez,Frederick A. Beland,Olga Kovalchuk +5 more
TL;DR: Findings indicate that miRNA changes occur prior to tumor formation and are not merely a consequence of a transformed state, as previously reported alterations in full-fledged tumors, including hepatocellular carcinomas.
Journal ArticleDOI
Intense THz pulses cause H2AX phosphorylation and activate DNA damage response in human skin tissue
Lyubov V. Titova,A. Ayesheshim,Andrey Golubov,Dawson Fogen,Rocio Rodriguez-Juarez,Frank A. Hegmann,Olga Kovalchuk +6 more
TL;DR: It is observed that exposure to intense THz pulses for ten minutes leads to a significant induction of H2AX phosphorylation, indicating that THz pulse irradiation may cause DNA damage in exposed skin tissue.
Journal ArticleDOI
Sex- and tissue-specific expression of maintenance and de novo DNA methyltransferases upon low dose X-irradiation in mice.
TL;DR: It is proved that changes in the expression of de novo methyltransferases DNMT3a and DNMT2b are the most important in radiation-induced DNA methylation alterations, and the role of sex hormones, especially estrogen, in the generation of the sex-specific radiation- induced methylation changes is discussed.
Journal ArticleDOI
Intense THz pulses down-regulate genes associated with skin cancer and psoriasis: a new therapeutic avenue?
Lyubov V. Titova,A. Ayesheshim,Andrey Golubov,Rocio Rodriguez-Juarez,Rafal Woycicki,Frank A. Hegmann,Olga Kovalchuk +6 more
TL;DR: It is shown that exposure of artificial human skin tissue to intense, picosecond-duration THz pulses affects expression levels of numerous genes associated with non-melanoma skin cancers, psoriasis and atopic dermatitis.