Roderick P. Martin

TL;DR: Osteoblastic cells are a regulatory component of the haematopoietic stem cell niche in vivo that influences stem cell function through Notch activation.

TL;DR: It is shown that pharmacologic use of PTH increases the number of HS cells mobilized into the peripheral blood for stem cell harvests, protects stem cells from repeated exposure to cytotoxic chemotherapy and expands stem cells in transplant recipients.

TL;DR: Analysis of clinical and genetic characteristics associated with circulating CD34(+) cell frequency in a large, community-based sample of 1786 Framingham Heart Study participants has implications for therapies that use CD34 (+) cell populations and support efforts to better understand the genetic mechanisms that underlie CD34-+) frequency.

TL;DR: It is hypothesized that methotrexate induction treatment concomitant with initial exposure to the biotherapeutic can induce Ag-specific immune tolerance in mice through a mechanism that appears to involve the induction of regulatory B cells.

TL;DR: In this large, community-based sample of men and women, lower colony-forming unit number was associated with a higher burden of subclinical atherosclerosis in the coronary arteries and aorta, suggesting decreased angiogenic potential could contribute to the development of atheros sclerosis in humans.