L
Laura M. Calvi
Researcher at University of Rochester Medical Center
Publications - 111
Citations - 7384
Laura M. Calvi is an academic researcher from University of Rochester Medical Center. The author has contributed to research in topics: Haematopoiesis & Bone marrow. The author has an hindex of 31, co-authored 97 publications receiving 6846 citations. Previous affiliations of Laura M. Calvi include Harvard University & University of Rochester.
Papers
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Journal ArticleDOI
Osteoblastic cells regulate the haematopoietic stem cell niche
Laura M. Calvi,Gregor B. Adams,Kathryn W. Weibrecht,Jonathan M. Weber,David P. Olson,M. C. Knight,Roderick P. Martin,Ernestina Schipani,P. Divieti,F. R. Bringhurst,Laurie A. Milner,Henry M. Kronenberg,David T. Scadden +12 more
TL;DR: Osteoblastic cells are a regulatory component of the haematopoietic stem cell niche in vivo that influences stem cell function through Notch activation.
Journal ArticleDOI
Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size.
Sebastian Stier,Yon Ko,Randolf Forkert,Randolf Forkert,Christoph Lutz,Christoph Lutz,Thomas Neuhaus,Elisabeth Grünewald,Tao Cheng,David Dombkowski,Laura M. Calvi,Susan R. Rittling,David T. Scadden +12 more
TL;DR: It is demonstrated that OPN modifies primitive hematopoietic cell number and function in a stem cell–nonautonomous manner and may provide a mechanism for restricting excess stem cell expansion under conditions of niche stimulation.
Journal ArticleDOI
Activated parathyroid hormone/parathyroid hormone–related protein receptor in osteoblastic cells differentially affects cortical and trabecular bone
Laura M. Calvi,Natalie A. Sims,J.L. Hunzelman,M. C. Knight,A. Giovannetti,J.M. Saxton,Henry M. Kronenberg,Roland Baron,Ernestina Schipani +8 more
TL;DR: These findings identify the PPR as a crucial mediator of both bone-forming and bone-resorbing actions of PTH, and underline the complexity and heterogeneity of the osteoblast population and/or their regulatory microenvironment.
Journal ArticleDOI
Therapeutic targeting of a stem cell niche.
Gregor B. Adams,Roderick P. Martin,Ian R. Alley,Karissa T. Chabner,Kenneth S. Cohen,Laura M. Calvi,Henry M. Kronenberg,David T. Scadden +7 more
TL;DR: It is shown that pharmacologic use of PTH increases the number of HS cells mobilized into the peripheral blood for stem cell harvests, protects stem cells from repeated exposure to cytotoxic chemotherapy and expands stem cells in transplant recipients.
Journal ArticleDOI
The hematopoietic stem cell niche in homeostasis and disease
Laura M. Calvi,Daniel C. Link +1 more
TL;DR: It is highlighted that stem cell niches in the bone marrow are not static but instead are responsive to environmental stimuli and how these alterations might contribute to disease pathogenesis is discussed.