Marko Loparic

TL;DR: It is shown using an indentation-type atomic force microscope (IT-AFM) that unadulterated human breast biopsies display distinct stiffness profiles, and evidence obtained from the lungs of mice with late-stage tumours shows that migration and metastatic spreading is correlated to the low stiffness of hypoxia-associated cancer cells.

TL;DR: It is proposed to use nanostiffness as a new biomarker to analyze structure-function relationships in normal, diseased, and engineered cartilage because the micrometer-scale measurements fail to resolve separate stiffness values for the PG and collagen fibril moieties.

TL;DR: Modulation of the oxygen percentage during HAC culture may be used to study pathophysiological events occurring in osteoarthritis and to enhance properties of in vitro engineered cartilaginous tissues.

TL;DR: In this article, an abbreviated ex vivo protocol using vector-laden, coagulated bone marrow aspirates for gene delivery to cartilage defects may be feasible for clinical application.

TL;DR: A detailed topographical and nanomechanical profile of native human ILM was generated using atomic force microscopy under physiological conditions and Interestingly, the foveal ILM displayed a craterlike morphological appearance with four distinct layers separated by comparatively steep thickness increments.