E
Ellen C. Obermann
Researcher at University of Basel
Publications - 81
Citations - 3282
Ellen C. Obermann is an academic researcher from University of Basel. The author has contributed to research in topics: Breast cancer & Tissue microarray. The author has an hindex of 27, co-authored 80 publications receiving 2904 citations. Previous affiliations of Ellen C. Obermann include University of Regensburg & University Hospital of Basel.
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Journal ArticleDOI
The nanomechanical signature of breast cancer
Marija Plodinec,Marko Loparic,Christophe A. Monnier,Ellen C. Obermann,Rosanna Zanetti-Dällenbach,Philipp Oertle,Janne T. Hyotyla,Ueli Aebi,Mohamed Bentires-Alj,Roderick Y. H. Lim,Cora-Ann Schoenenberger +10 more
TL;DR: It is shown using an indentation-type atomic force microscope (IT-AFM) that unadulterated human breast biopsies display distinct stiffness profiles, and evidence obtained from the lungs of mice with late-stage tumours shows that migration and metastatic spreading is correlated to the low stiffness of hypoxia-associated cancer cells.
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The presence of programmed death 1 (PD-1)-positive tumor-infiltrating lymphocytes is associated with poor prognosis in human breast cancer
Simone Muenst,Simone Muenst,Savas D. Soysal,Savas D. Soysal,Feng Gao,Ellen C. Obermann,Daniel Oertli,William E. Gillanders +7 more
TL;DR: This is the first study to demonstrate that the presence ofPD-1+ TIL is associated with poor prognosis in human breast cancer, with important implications for the potential application of antibody therapies targeting the PD-1/PD-L1 signaling pathway in this disease.
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How Reliable Is Ki-67 Immunohistochemistry in Grade 2 Breast Carcinomas? A QA Study of the Swiss Working Group of Breast- and Gynecopathologists
Zsuzsanna Varga,Joachim Diebold,Corina Dommann-Scherrer,Harald Frick,Daniela Kaup,Aurelia Noske,Ellen C. Obermann,Christian Öhlschlegel,Barbara Padberg,Christiane Rakozy,Sara Sancho Oliver,Sylviane Schobinger-Clement,Heide Schreiber-Facklam,Gad Singer,Coya Tapia,Urs Wagner,Mauro G. Mastropasqua,Giuseppe Viale,Hans A. Lehr +18 more
TL;DR: Assessment of mid-range Ki-67-LI suffers from high inter- and intra-observer variability, and oncologists should be aware of this caveat when using Ki- 67-LI as a basis for treatment decisions in moderately differentiated breast carcinomas.
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Frequent genetic alterations in flat urothelial hyperplasias and concomitant papillary bladder cancer as detected by CGH, LOH, and FISH analyses.
Ellen C. Obermann,Kerstin Junker,Robert Stoehr,Wolfgang Dietmaier,Dirk Zaak,Jörg Schubert,Ferdinand Hofstaedter,Ruth Knuechel,Arndt Hartmann +8 more
TL;DR: The hypothesis that flat urothelial hyperplasias can display many genetic alterations commonly found in bladder cancer and could therefore be an early neoplastic lesion in the multistep development of invasive u rothelial carcinoma is supported.
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EpCAM expression varies significantly and is differentially associated with prognosis in the luminal B HER2(+), basal-like, and HER2 intrinsic subtypes of breast cancer.
Savas D. Soysal,Simone Muenst,Simone Muenst,Thanh U. Barbie,Timothy P. Fleming,Feng Gao,Gilbert Spizzo,Daniel Oertli,Carsten T. Viehl,Ellen C. Obermann,William E. Gillanders +10 more
TL;DR: In the intrinsic subtypes, EpCAM expression was associated with an unfavourable prognosis in the basal-like and luminal B HER2+ subtypes but associated with a favourable prog outlook in the HER2 subtype.