Roel Quintens

TL;DR: Gene array studies of ulcerative colitis mucosal biopsies identified predictive panels of genes for (non-response) response to infliximab, and further study of the pathways involved should allow a better understanding of the mechanisms of resistance to inflIXimab therapy in ulceratives colitis.

TL;DR: It is proposed that the NADPH/GRX/TRX redox regulation mediates a novel signaling pathway of nutrient-induced insulin secretion in neuroendocrine cells.

TL;DR: It is concluded that IL-6 is necessary for the expansion of pancreatic α-cell mass in response to high-fat diet feeding, and it is suggested that this expansion may be needed for functional β-cell compensation to increased metabolic demand.

TL;DR: The study shows that the dysregulation of AMPs in IBD mucosa is the consequence of inflammation, but may be responsible for perpetuation of inflammation due to ineffective clearance of microorganisms.

TL;DR: Promoter-activating mutations in EIHI induce SLC16A1 expression in beta cells, permitting pyruvate uptake and pyruVate-stimulated insulin release despite ensuing hypoglycemia, describing a novel disease mechanism based on the failure of cell-specific transcriptional silencing of a gene that is highly expressed in other tissues.