R
Roeltje R. Maas
Researcher at Ludwig Institute for Cancer Research
Publications - 7
Citations - 559
Roeltje R. Maas is an academic researcher from Ludwig Institute for Cancer Research. The author has contributed to research in topics: Brain metastasis & Immune system. The author has an hindex of 3, co-authored 5 publications receiving 182 citations. Previous affiliations of Roeltje R. Maas include University of Lausanne & University Hospital of Lausanne.
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Journal ArticleDOI
Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells
Florian Klemm,Florian Klemm,Roeltje R. Maas,Robert L. Bowman,Mara Kornete,Mara Kornete,Klara Soukup,Klara Soukup,Sina Nassiri,Sina Nassiri,Sina Nassiri,Jean-Philippe Brouland,Christine A. Iacobuzio-Donahue,Cameron Brennan,Viviane Tabar,Philip H. Gutin,Roy Thomas Daniel,Monika E. Hegi,Johanna A. Joyce,Johanna A. Joyce +19 more
TL;DR: These integrated analyses uncovered multifaceted immune cell activation within brain malignancies entailing converging transcriptional trajectories while maintaining disease- and cell-type-specific programs.
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Central memory CD8+ T cells derive from stem-like Tcf7hi effector cells in the absence of cytotoxic differentiation.
Daniela Pais Ferreira,Joana Gomes Silva,Tania Wyss,Silvia A. Fuertes Marraco,Leonardo Scarpellino,Mélanie Charmoy,Roeltje R. Maas,Roeltje R. Maas,Roeltje R. Maas,Imran Siddiqui,Li Tang,Johanna A. Joyce,Johanna A. Joyce,Mauro Delorenzi,Mauro Delorenzi,Sanjiv A. Luther,Daniel E. Speiser,Werner Held +17 more
TL;DR: Rare effector-phase CD8+ T cells expressing high amounts of the transcription factor Tcf1 that showed no evidence of prior cytolytic differentiation and that displayed key hallmarks of Tcm cells are uncovered.
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Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis
Florian Klemm,Florian Klemm,Aylin Möckl,Anna Salamero-Boix,Tijna Alekseeva,Alexander Schaffer,Michael Schulz,Katja Niesel,Roeltje R. Maas,Marie Groth,Benelita T. Elie,Robert L. Bowman,Monika E. Hegi,Roy Thomas Daniel,Pia S. Zeiner,Jenny Zinke,Patrick N. Harter,Karl H. Plate,Johanna A. Joyce,Johanna A. Joyce,Lisa Sevenich +20 more
TL;DR: It is demonstrated that targeting TAMs at distinct stages of the metastatic cascade using an inhibitor of colony-stimulating factor 1 receptor (CSF1R), BLZ945, in murine breast-to-brain metastasis models leads to antitumor responses in prevention and intervention preclinical trials.
Journal ArticleDOI
An integrated pipeline for comprehensive analysis of immune cells in human brain tumor clinical samples.
Roeltje R. Maas,Klara Soukup,Klara Soukup,Florian Klemm,Florian Klemm,Mara Kornete,Mara Kornete,Robert L. Bowman,Romain Bedel,Damien N. Marie,Damien N. Marie,Ángel F. Álvarez-Prado,Ángel F. Álvarez-Prado,Danny Labes,Anne Wilson,Jean-Philippe Brouland,Roy Thomas Daniel,Monika E. Hegi,Johanna A. Joyce,Johanna A. Joyce +19 more
TL;DR: A multimodule integrated pipeline for the processing of freshly resected human brain tumor tissue and matched blood that enables analysis of the tumor microenvironment, with a particular focus on the tumor immune microenvironment (TIME).
Journal ArticleDOI
Immunogenomic analysis of human brain metastases reveals diverse immune landscapes across genetically distinct tumors
Ángel F. Álvarez-Prado,Roeltje R. Maas,Klara Soukup,Florian Klemm,Mara Kornete,F. Krebs,Vincent Zoete,Sabina Berezowska,Jean-Philippe Brouland,Andreas F. Hottinger,Roy T. Daniel,Monika E. Hegi,Johanna A. Joyce +12 more
TL;DR: In this article , the authors performed an extensive characterization of the immunogenomic landscape of human BrMs by combining whole-exome/whole-genome sequencing, RNA sequencing of immune cell populations, flow cytometry, immunofluorescence staining, and tissue imaging analyses.