R
Rolf W. Hartmann
Researcher at Saarland University
Publications - 371
Citations - 8686
Rolf W. Hartmann is an academic researcher from Saarland University. The author has contributed to research in topics: Aromatase & Enzyme. The author has an hindex of 47, co-authored 365 publications receiving 7834 citations. Previous affiliations of Rolf W. Hartmann include University of Regensburg & Free University of Berlin.
Papers
More filters
Journal ArticleDOI
Novel Strategies for the Treatment of Pseudomonas aeruginosa Infections
Stefanie Wagner,Roman Sommer,Stefan Hinsberger,Cenbin Lu,Rolf W. Hartmann,Martin Empting,Alexander Titz +6 more
TL;DR: It can be expected that combination therapies, also containing antivirulence agents, will pave the way toward novel treatment options against P. aeruginosa, and antivirulent drugs are expected to yield a significantly reduced rate of resistance development.
Journal ArticleDOI
17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development.
Sandrine Marchais-Oberwinkler,Claudia Henn,Gabriele Möller,Tobias Klein,Matthias Negri,Alexander Oster,Alessandro Spadaro,Ruth Werth,Marie Wetzel,Kuiying Xu,Martin Frotscher,Rolf W. Hartmann,Jerzy Adamski +12 more
TL;DR: An overview of functional and structural aspects for the different 17β-HSDs is given and the selective inhibition of the concerned enzymes might provide an effective treatment and a good alternative to the existing endocrine therapies.
Journal ArticleDOI
Antibiotic-free nanotherapeutics: ultra-small, mucus-penetrating solid lipid nanoparticles enhance the pulmonary delivery and anti-virulence efficacy of novel quorum sensing inhibitors.
Noha Nafee,Ayman Husari,Christine K. Maurer,Cenbin Lu,Chiara De Rossi,Anke Steinbach,Rolf W. Hartmann,Claus-Michael Lehr,Marc Schneider +8 more
TL;DR: In this context, various pharmaceutical lipids were used to prepare ultra-small solid lipid nanoparticles (us-SLNs) by hot melt homogenization, which exhibited anti-virulence properties themselves, which was shown to be related to anti- virulence effects of the emulsifiers used.
Journal ArticleDOI
Discovery of Antagonists of PqsR, a Key Player in 2-Alkyl-4-quinolone-Dependent Quorum Sensing in Pseudomonas aeruginosa
Cenbin Lu,Benjamin Kirsch,Christina Zimmer,Johannes C. de Jong,Claudia Henn,Christine K. Maurer,Mathias Müsken,Susanne Häussler,Anke Steinbach,Rolf W. Hartmann +9 more
TL;DR: In vitro evaluation using a reporter gene assay in Escherichia coli led to the discovery of the first competitive PqsR antagonists, which are highly potent (K(d,app) of compound 20: 7 nM).
Journal ArticleDOI
Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones
Rolf W. Hartmann,Christine Batzl +1 more
TL;DR: Being stronger and more selective inhibitors of the estrogen biosynthesis than AG, some of the newly developed derivatives of AG might be better candidates for the treatment of the hormone-dependent human breast cancer.