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Chiara De Rossi
Researcher at Saarland University
Publications - 10
Citations - 364
Chiara De Rossi is an academic researcher from Saarland University. The author has contributed to research in topics: Drug delivery & Bacterial outer membrane. The author has an hindex of 9, co-authored 10 publications receiving 271 citations. Previous affiliations of Chiara De Rossi include Korea Institute of Science and Technology.
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Journal ArticleDOI
Antibiotic-free nanotherapeutics: ultra-small, mucus-penetrating solid lipid nanoparticles enhance the pulmonary delivery and anti-virulence efficacy of novel quorum sensing inhibitors.
Noha Nafee,Ayman Husari,Christine K. Maurer,Cenbin Lu,Chiara De Rossi,Anke Steinbach,Rolf W. Hartmann,Claus-Michael Lehr,Marc Schneider +8 more
TL;DR: In this context, various pharmaceutical lipids were used to prepare ultra-small solid lipid nanoparticles (us-SLNs) by hot melt homogenization, which exhibited anti-virulence properties themselves, which was shown to be related to anti- virulence effects of the emulsifiers used.
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Kinetics of mRNA delivery and protein translation in dendritic cells using lipid-coated PLGA nanoparticles.
Hanzey Yasar,Alexander Biehl,Chiara De Rossi,Marcus Koch,Xabi Murgia,Brigitta Loretz,Claus-Michael Lehr +6 more
TL;DR: While cellular uptake of both NP types was comparable, mRNA transgene expression was superior to polymer-based NPs when delivered by lipid–polymer NPs.
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Farnesylated Glycol Chitosan as a Platform for Drug Delivery: Synthesis, Characterization, and Investigation of Mucus-Particle Interactions.
Duy-Khiet Ho,Sarah Frisch,Alexander Biehl,Emmanuel Terriac,Chiara De Rossi,Konrad Schwarzkopf,Franziska Lautenschläger,Brigitta Loretz,Xabier Murgia,Claus-Michael Lehr +9 more
TL;DR: A facile method for synthesizing a new amphiphilic polymer, farnesylated glycol chitosan (FGC), which self-assembles into nanoparticles upon being dispersed in aqueous media is proposed, postulate FGC as a versatile drug delivery platform.
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PLGA nanocapsules improve the delivery of clarithromycin to kill intracellular Staphylococcus aureus and Mycobacterium abscessus.
Frantiescoli Anversa Dimer,Cristiane de Souza Carvalho-Wodarz,Adriely Goes,Katarina Cirnski,Jennifer Herrmann,Viktoria Schmitt,Linda Pätzold,Nadia Abed,Chiara De Rossi,Markus Bischoff,Patrick Couvreur,Rolf Müller,Claus-Michael Lehr +12 more
TL;DR: Clinithromycin-nanocapsules are a promising strategy to target intracellular S. aureus and M. abscessus and suggest an improved delivery to sub-epithelial tissues.
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Starch-Chitosan Polyplexes: A Versatile Carrier System for Anti-Infectives and Gene Delivery.
Hanzey Yasar,Duy-Khiet Ho,Chiara De Rossi,Jennifer Herrmann,Sarah Gordon,Brigitta Loretz,Claus-Michael Lehr +6 more
TL;DR: Starch-chitosan complexes are suitable carriers with promising perspectives for pharmaceutical use and careful adjustment of C/N ratio, polymer concentration and molecular weight allowed for tuning of particle characteristics.