R
Romain J.T. Leboux
Researcher at Leiden University
Publications - 8
Citations - 134
Romain J.T. Leboux is an academic researcher from Leiden University. The author has contributed to research in topics: Liposome & Antigen. The author has an hindex of 4, co-authored 6 publications receiving 86 citations. Previous affiliations of Romain J.T. Leboux include Statens Serum Institut.
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Journal ArticleDOI
Anionic 1,2-distearoyl-sn-glycero-3-phosphoglycerol (DSPG) liposomes induce antigen-specific regulatory T cells and prevent atherosclerosis in mice.
Naomi Benne,Janine van Duijn,Fernando Lozano Vigario,Romain J.T. Leboux,Peter A. van Veelen,Johan Kuiper,Wim Jiskoot,Bram Slütter +7 more
TL;DR: It is reported that liposomes containing the anionic phospholipid 1,2‐distearoyl‐sn‐glycero‐3‐phosphoglycerol (DSPG) induce Tregs that are specific for the liposome’ cargo, indicating that DSPG‐liposomes have potential as a delivery system in vaccination against atherosclerosis.
Journal ArticleDOI
Nanolayered chemical modification of silicon surfaces with ionizable surface groups for pH-triggered protein adsorption and release: application to microneedles
Koen van der Maaden,Huixin Yu,Karen Sliedregt,Raphaël Zwier,Romain J.T. Leboux,Masashi Oguri,Alexander Kros,Wim Jiskoot,Joke A. Bouwstra +8 more
TL;DR: A procedure to efficiently coat microneedle arrays with proteins that are released upon piercing into human skin by developing a nanolayered pH sensitive coating method.
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Atomic force microscopy measurements of anionic liposomes reveal the effect of liposomal rigidity on antigen-specific regulatory T cell responses.
Naomi Benne,Romain J.T. Leboux,Marco Glandrup,Janine van Duijn,Fernando Lozano Vigario,Malene Aaby Neustrup,Stefan Romeijn,F. Galli,Johan Kuiper,Wim Jiskoot,Bram Slütter +10 more
TL;DR: It is shown that rigidity positively correlates with Treg responses in vitro in murine DCs and in vivo in mice, underline the suitability of AFM to measure liposome rigidity and the importance of this parameter when designing liposomes as a vaccine delivery system.
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A Liposome Based Adjuvant Containing Two Delivery Systems with the Ability to Induce Mucosal Immunoglobulin A Following a Parenteral Immunization
Dennis Christensen,Lasse Bøllehuus Hansen,Romain J.T. Leboux,Romain J.T. Leboux,Wim Jiskoot,Jan Pravsgaard Christensen,Peter Andersen,Jes Dietrich +7 more
TL;DR: It is shown that CAF23, administered by the subcutaneous route induces an antigen specific intestinal IgA response, making it a promising candidate adjuvant for vaccines against enteric diseases.
Journal ArticleDOI
Antigen uptake after intradermal microinjection depends on antigen nature and formulation, but not on injection depth
Romain J.T. Leboux,Pim Schipper,T.M.M. van Capel,L. Kong,L. Kong,K. van der Maaden,Alexander Kros,Wim Jiskoot,E.C. de Jong,Johanna Aaltje Bouwstra +9 more
TL;DR: In this paper, the authors used a hollow microneedle injection system to inject Bet v 1 and OVA formulations in ex vivo human skin in a depth-controlled manner.