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Roman V. Lenchine
Researcher at University of Adelaide
Publications - 9
Citations - 126
Roman V. Lenchine is an academic researcher from University of Adelaide. The author has contributed to research in topics: EEF2 & Protein biosynthesis. The author has an hindex of 4, co-authored 6 publications receiving 74 citations. Previous affiliations of Roman V. Lenchine include University of South Australia.
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Journal ArticleDOI
Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan
Jianling Xie,Viviane de Souza Alves,Tobias von der Haar,Louise V. O'Keefe,Roman V. Lenchine,Kirk B. Jensen,Rui Liu,Mark J. Coldwell,Xuemin Wang,Christopher G. Proud +9 more
TL;DR: The data uncover a novel mechanism linking nutrient supply, mTORC1 signaling, and the elongation stage of protein synthesis, which enhances the accuracy ofprotein synthesis and indicates that modulating translation elongation and its fidelity affects lifespan.
Journal ArticleDOI
Eukaryotic elongation factor 2 kinase upregulates the expression of proteins implicated in cell migration and cancer cell metastasis
Jianling Xie,Kaikai Shen,Roman V. Lenchine,Lee A. Gethings,Paul J. Trim,Marten F. Snel,Ying Zhou,Justin W. Kenney,Makoto Kamei,Marina Kochetkova,Xuemin Wang,Xuemin Wang,Christopher G. Proud +12 more
TL;DR: Evidence is provided that eEF2K is a new potential therapeutic target for preventing tumor metastasis and genetic knock down or pharmacological inhibition of e EF2K reduces the protein expression levels of integrins.
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eEF2K enhances expression of PD-L1 by promoting the translation of its mRNA.
Yu Wu,Jianling Xie,Xin Jin,Roman V. Lenchine,Xuemin Wang,Danielle M. Fang,Zeyad D. Nassar,Lisa M. Butler,Jing Li,Christopher G. Proud +9 more
TL;DR: The data reveal that eEF2K regulates PD-L1 expression at the level of the translation of its mRNA by virtue of a uORF in its 5'-region which starts with a non-canonical CUG as the initiation codon.
Journal ArticleDOI
Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis.
Jianling Xie,Kaikai Shen,Kaikai Shen,Ashley T. Jones,Jian Yang,Andrew R. Tee,Ming Hong Shen,Mengyuan Yu,Swati Irani,Derick Wong,James E. Merrett,James E. Merrett,Roman V. Lenchine,Roman V. Lenchine,Stuart P. De Poi,Stuart P. De Poi,Kirk B. Jensen,Paul J. Trim,Marten F. Snel,Makoto Kamei,Sally Martin,Stephen Fitter,Shuye Tian,Shuye Tian,Xuemin Wang,Lisa M. Butler,Andrew C.W. Zannettino,Christopher G. Proud +27 more
TL;DR: A novel feedback loop is defined whereby mTORC1 represses MNK2 activity and oncogenic signaling through eIF4E phosphorylation, allowing reciprocal regulation of these twoOncogenic pathways.
Journal ArticleDOI
Elongation factor eEF2 kinase and autophagy jointly promote survival of cancer cells.
TL;DR: In this article, the roles of autophagy and elongation factor 2 kinase (eEF2K) were explored in the absence of key nutrients, using cancer cells in culture.