R
Ronald Breslow
Researcher at Columbia University
Publications - 541
Citations - 37421
Ronald Breslow is an academic researcher from Columbia University. The author has contributed to research in topics: Catalysis & Cyclodextrin. The author has an hindex of 92, co-authored 541 publications receiving 35903 citations. Previous affiliations of Ronald Breslow include Hunter College & Center for Functional Nanomaterials.
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Journal ArticleDOI
Histone deacetylases and cancer: causes and therapies.
Paul A. Marks,Richard A. Rifkind,Victoria M. Richon,Ronald Breslow,Thomas E. Miller,William Kevin Kelly +5 more
TL;DR: Together, histone acetyltransferases and histone deacetylases determine the acetylation status of histones, and inhibitors of HDACs have been found to cause growth arrest, differentiation and/or apoptosis of many tumours cells by altering the transcription of a small number of genes.
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Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors.
Michael S. Finnin,Jill R. Donigian,Alona Cohen,Victoria M. Richon,Richard A. Rifkind,Paul A. Marks,Ronald Breslow,Nikola P. Pavletich +7 more
TL;DR: The structure of the histone deacetylase catalytic core is described, as revealed by the crystal structure of a homologue from the hyperthermophilic bacterium Aquifex aeolicus, and it is established that the residues that make up the active site and contact the inhibitors are conserved across the HDAC family.
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Hydrophobic acceleration of Diels-Alder reactions
Darryl Rideout,Ronald Breslow +1 more
Journal ArticleDOI
Biomimetic Reactions Catalyzed by Cyclodextrins and Their Derivatives.
Ronald Breslow,Suwei Dong +1 more
TL;DR: This review will cover all the literature on reactions in which cyclodextrins bind substrates and then either catalyze their reactions or mimic a step in an enzymatic catalytic sequence, however, it will not describe work in which Cyclodextrin simply change the course of a reaction without playing an obvious catalytic role involving substrate binding.