Ronald E. Ferrando

TL;DR: The results identify USP9X as a prognostic and therapeutic target, and they show that deubiquitinases may stabilize labile oncoproteins in human malignancies.

TL;DR: This work has developed linkage-specific antibodies that recognize polyubiquitin chains joined through lysine 63 (K63) or 48 (K48) and uses these antibodies to demonstrate that RIP1, which is essential for tumor necrosis factor-induced NF-kappaB activation, and IRAK1, who participates in signaling by interleukin-1beta and Toll-like receptors, both undergo polyubiquein editing in stimulated cells.

TL;DR: The data indicate that the kinase activity of RIPK3 is essential for necroptosis but also governs whether a cell activates caspase-8 and dies by apoptosis.

TL;DR: It is concluded that airway smooth muscle proliferation is a pathologic characteristic of subjects with mild to moderate asthma, however, smooth muscle cells in mild tomoderate asthma do not show hypertrophy or gene expression changes of a hypercontractile phenotype observed in vitro.

TL;DR: CGI1746 is described, a small-molecule Btk inhibitor chemotype with a new binding mode that stabilizes an inactive nonphosphorylated enzyme conformation that decreases cytokine levels within joints and ameliorates disease.