O
Owen D. Solberg
Researcher at Sandia National Laboratories
Publications - 37
Citations - 4052
Owen D. Solberg is an academic researcher from Sandia National Laboratories. The author has contributed to research in topics: Genotype & Periostin. The author has an hindex of 26, co-authored 37 publications receiving 3629 citations. Previous affiliations of Owen D. Solberg include University of California, San Francisco & University of California, Berkeley.
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Journal ArticleDOI
Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients.
Guiquan Jia,Richard W. Erickson,David F. Choy,Sofia Mosesova,Lawren C. Wu,Owen D. Solberg,Aarti Shikotra,Richard Carter,Severine Audusseau,Qutayba Hamid,Peter Bradding,Peter Bradding,John V. Fahy,Prescott G. Woodruff,Jeffrey M. Harris,Joseph R. Arron +15 more
TL;DR: Periostin is a systemic biomarker of airway eosinophilia in asthmatic patients and has potential utility in patient selection for emerging asthma therapeutics targeting T(H)2 inflammation.
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Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression.
Prescott G. Woodruff,Gregory Dolganov,Ronald E. Ferrando,Samantha Donnelly,Steven R. Hays,Owen D. Solberg,Roderick Carter,Hofer Wong,Peggy S. Cadbury,John V. Fahy +9 more
TL;DR: It is concluded that airway smooth muscle proliferation is a pathologic characteristic of subjects with mild to moderate asthma, however, smooth muscle cells in mild tomoderate asthma do not show hypertrophy or gene expression changes of a hypercontractile phenotype observed in vitro.
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Balancing selection and heterogeneity across the classical human leukocyte antigen loci: a meta-analytic review of 497 population studies.
Owen D. Solberg,Steven J. Mack,Alex K. Lancaster,Richard M. Single,Yingssu Tsai,Alicia Sanchez-Mazas,Glenys Thomson +6 more
TL;DR: A role for balancing selection maintaining much of HLA variation was confirmed and the ranking of the HLA loci was confirmed, with DQA1 and HLA-C showing the strongest balancing selection and DPB1 being compatible with neutrality.
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Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction
Fen Huang,Hongkang Zhang,Meng Wu,Huanghe Yang,Huanghe Yang,Makoto Kudo,Makoto Kudo,Christian J. Peters,Christian J. Peters,Prescott G. Woodruff,Owen D. Solberg,Matthew Donne,Xiaozhu Huang,Dean Sheppard,John V. Fahy,Paul J. Wolters,Brigid L.M. Hogan,Walter E. Finkbeiner,Min Li,Yuh Nung Jan,Yuh Nung Jan,Lily Yeh Jan,Lily Yeh Jan,Jason R. Rock +23 more
TL;DR: It is shown that the recently identified calcium-activated chloride channel (CaCC) TMEM16A is expressed in the adult airway surface epithelium and ASM and significantly reduces mouse and human ASM contraction in response to cholinergic agonists.
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PyPop update – a software pipeline for large‐scale multilocus population genomics
TL;DR: PyPop (Python for Population Genomics) is an open-source framework for performing large-scale population genetic analyses on multilocus genotype data that computes the statistics described above, among others.