R
Ronald F. Pfeiffer
Researcher at Oregon Health & Science University
Publications - 169
Citations - 13734
Ronald F. Pfeiffer is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Parkinson's disease & Parkinsonism. The author has an hindex of 53, co-authored 166 publications receiving 12568 citations. Previous affiliations of Ronald F. Pfeiffer include University of Nebraska Medical Center & University of Tennessee Health Science Center.
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Journal ArticleDOI
Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology
Alexander Zimprich,Alexander Zimprich,Saskia Biskup,Petra Leitner,Peter Lichtner,Matthew J. Farrer,Sarah Lincoln,Jennifer M. Kachergus,Mary M. Hulihan,Ryan J. Uitti,Donald B. Calne,A. Jon Stoessl,Ronald F. Pfeiffer,Nadja Patenge,Iria Carballo Carbajal,Peter Vieregge,Friedrich Asmus,Bertram Müller-Myhsok,Dennis W. Dickson,Thomas Meitinger,Tim M. Strom,Zbigniew K. Wszolek,Thomas Gasser +22 more
TL;DR: High-resolution recombination mapping and candidate gene sequencing in 46 families found six disease-segregating mutations in a gene encoding a large, multifunctional protein, LRRK2 (leucine-rich repeat kinase 2), which may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism.
Journal ArticleDOI
Pramipexole vs levodopa as initial treatment for Parkinson disease: a 4-year randomized controlled trial.
Robert G. Holloway,Ira Shoulson,Stanley Fahn,Karl Kieburtz,Anthony E. Lang,Kenneth Marek,Michael P. McDermott,John Seibyl,William J. Weiner,Bruno Musch,Cornelia Kamp,Mickie Welsh,Aileen Shinaman,Rajesh Pahwa,Lynn Barclay,Jean P. Hubble,Peter A. LeWitt,Janis M. Miyasaki,Oksana Suchowersky,Mark Stacy,David S. Russell,Blair Ford,John P. Hammerstad,David E. Riley,David G. Standaert,Frederick Wooten,Stewart A. Factor,Joseph Jankovic,Farah Atassi,Roger Kurlan,Michel Panisset,Ali H. Rajput,Robert L. Rodnitzky,Cliff Shults,Giselle Petsinger,Cheryl Waters,Ronald F. Pfeiffer,Kevin M. Biglan,Leona Borchert,Amy Montgomery,Laura Sutherland,Carolyn Weeks,Maryan DeAngelis,Elspeth Sime,Susan Wood,Carol Pantella,Mary Harrigan,Barbara Fussell,Sandra Dillon,Barbara Alexander-Brown,Pamela Rainey,Marsha Tennis,Elke Rost-Ruffner,Diane Brown,Sharon Evans,Debra Berry,Jean Hall,Theresa Shirley,Judith Dobson,Deborah Fontaine,Brenda Pfeiffer,Alicia Brocht,Susan E. Bennett,Susan Daigneault,Karen Hodgeman,Carolynn O'Connell,Tori Ross,Karen Richard,Arthur Watts +68 more
TL;DR: Initial treatment with pramipexole resulted in lower incidences of freezing, somnolence, and edema and provided for better symptomatic control, as measured by the Unified Parkinson's Disease Rating Scale, compared with initial treatment with levodopa, which resulted in similar quality of life.
Journal ArticleDOI
Gastrointestinal dysfunction in Parkinson's disease.
TL;DR: There is growing recognition that gastrointestinal dysfunction is common in Parkinson's disease (PD). Virtually all parts of the gastrointestinal tract can be affected, in some cases early in the disease course as discussed by the authors.
Journal Article
Gastrointestinal dysfunction in Parkinson's disease.
TL;DR: The presence of pervasive α-synuclein deposition in the gastrointestinal tract strongly implicates this system in the pathogenesis of Parkinson's disease and holds potential for early disease detection and development of neuroprotective approaches.
Journal ArticleDOI
Gastrointestinal symptoms in Parkinson's disease.
TL;DR: Investigating the prevalence of gastrointestinal symptoms in 98 individuals with Parkinson's disease and in a control group of 50 suggests that the GI symptoms of PD reflect direct involvement in the GI tract by the primary disease process.