Showing papers by "Rosalyn S. Yalow published in 1985"
TL;DR: This report describes the extraction of guinea pig (GP) intestinal VIP, its purification and sequence, and further evidence that the GP gastroenteropancreatic axis has a unique evolutionary separation from other mammals.
87 citations
TL;DR: Fractionation on Sephadex G50 gel of methanol extracts of guinea pig intestine reveals two molecular forms of cholecystokinin (CCK) of about equal abundance.
48 citations
TL;DR: The amino acid sequence of dog VIP is identical with all the mammalian VIP's which have been reported, which suggests that a high degree of conservation throughout the molecule may be required for VIP bioactivity.
23 citations
TL;DR: GP "little" gastrins I and II are hexadecapeptides due to a deletion of a glutamic acid in the region 6-9 from the N-terminus due to the presence of sulfate on the tyrosine of the latter.
11 citations
TL;DR: These findings are consistent with in vivo studies which have demonstrated that the dog kidney is an important site for extraction and degradation of endogenous dog gastrin but there is little or no hepatic removal of G34.
4 citations
Journal Article•
1 citations
TL;DR: The ready availability of inexpensive radioisotopes from the Oak Ridge reactor at the end of World War II led to the burgeoning application of these materials in biomedical investigation and the development of a new medical specialty, Nuclear Medicine as mentioned in this paper.
Abstract: The ready availability of inexpensive radioisotopes from the Oak Ridge reactor at the end of World War II led to the burgeoning application of these materials in biomedical investigation and the development of a new medical specialty, Nuclear Medicine. Much of this specialty is concerned with imaging, that is, administering a radioactive material to a patient and tracing its behavior in the body. Another important application is radioimmunoassay (RIA) an in vitro test that has become a major tool in thousands of laboratories around the world to measure concentrations in body fluids of hundreds, if not thousands, of substances of biologic interest. The concentmtion of an unknown substance is determined by comparing its inhibition of binding of a radioactively labeled tracer to specific antibody with the inhibitions observed with known standards. Whether these uses of radioisotopes will remain viable in the face of the pervasive fear of radiation exposure at any level is a cause for concern. The gen...