R
Rüdiger Arnold
Researcher at German Cancer Research Center
Publications - 12
Citations - 1227
Rüdiger Arnold is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: IκB kinase & T-cell receptor. The author has an hindex of 11, co-authored 12 publications receiving 1146 citations. Previous affiliations of Rüdiger Arnold include Max Planck Society.
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Journal ArticleDOI
Life and death in peripheral T cells
TL;DR: The concepts of activation-induced cell death (AICD) and activated cell-autonomous death (ACAD) in the regulation of life and death in T cells are discussed.
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Concepts of activated T cell death
TL;DR: The regulation of AICD and ACAD in T cells is discussed and the role of cytokines, T cell receptor (TCR) proximal signaling mediators like hematopoietic progenitor kinase 1 (HPK1) and the NF-kappaB pathway is reviewed.
Journal ArticleDOI
How T lymphocytes switch between life and death.
TL;DR: Activated T cells posses cell death escape mechanisms which are needed for survival of (memory) T cells, but are deleterious for autoimmune disorders or progression of T cell lymphomas.
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Activation or suppression of NFκB by HPK1 determines sensitivity to activation‐induced cell death
TL;DR: A novel mechanism of sensitization of T lymphocytes towards AICD by suppression of NFκB is shown, and it is proposed that HPK1 is a life/death switch in T lymphocyte.
Journal ArticleDOI
B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1.
Sachiyo Tsuji,Mariko Okamoto,Koichi Yamada,Noriaki Okamoto,Ryo Goitsuka,Ryo Goitsuka,Rüdiger Arnold,Friedemann Kiefer,Daisuke Kitamura +8 more
TL;DR: A novel BCR signaling pathway leading to the activation of HPK1 and subsequently IKKβ is revealed, in which BASH recruits tyrosine-phosphorylated HPK 1 into the B CR signaling complex.