Rudolf Graf

TL;DR: Treatment strategies are suggested which may be used to prevent or attenuate secondary neuronal damage in acutely injured human brain cortex caused by depolarization waves, which implicates CSD as a pathophysiological mechanism for this group of acute neurological disorders.

TL;DR: CSD and PID are described in patients with malignant middle cerebral artery infarction detected by subdural electrocorticography (ECoG) and found to cause secondary neuronal damage and infarct expansion.

TL;DR: From experimental data, the concept of single-drug intervention cannot be effective and further experimental research is needed, especially of the study of biochemical markers of the injury process to establish the role of several drugs.

TL;DR: The spreading depolarization continuum further applies to other models of acute cortical lesions, suggesting that it is a universal principle of cortical lesion development.

TL;DR: A number of scanner parameters such as spatial resolution, sensitivity, scatter, and count rate performance were determined in this work, which showed that the microPET R4 is a suitable PET scanner for small animals like mice and rats.