R
Rudolf Pullmann
Researcher at National Institutes of Health
Publications - 19
Citations - 2452
Rudolf Pullmann is an academic researcher from National Institutes of Health. The author has contributed to research in topics: RNA-binding protein & Three prime untranslated region. The author has an hindex of 16, co-authored 19 publications receiving 2304 citations.
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Journal ArticleDOI
Phosphorylation of HuR by Chk2 regulates SIRT1 expression
Kotb Abdelmohsen,Rudolf Pullmann,Ashish Lal,Hyeon Ho Kim,Stefanie Galbán,Xiaoling Yang,Justin D. Blethrow,Mark Walker,Jonathan Shubert,David A. F. Gillespie,Henry Furneaux,Myriam Gorospe +11 more
TL;DR: The findings demonstrate that HuR regulates SIRT1 expression, underscore functional links between the two stress-response proteins, and implicate Chk2 in these processes.
Journal ArticleDOI
p16INK4a Translation Suppressed by miR-24
Ashish Lal,Ashish Lal,Hyeon Ho Kim,Kotb Abdelmohsen,Yuki Kuwano,Rudolf Pullmann,Subramanya Srikantan,Ramesh Subrahmanyam,Jennifer L. Martindale,Xiaoling Yang,Fariyal Ahmed,Francisco Navarro,Derek M. Dykxhoorn,Judy Lieberman,Myriam Gorospe +14 more
TL;DR: It is reported that the microRNA miR-24 suppresses p16 expression in human diploid fibroblasts and cervical carcinoma cells and represses the initiation and elongation phases of p16 translation.
Journal ArticleDOI
RNA-Binding Proteins HuR and PTB Promote the Translation of Hypoxia-Inducible Factor 1α
Stefanie Galbán,Yuki Kuwano,Rudolf Pullmann,Jennifer L. Martindale,Hyeon Ho Kim,Ashish Lal,Kotb Abdelmohsen,Xiaoling Yang,Youngjun Dang,Jun O. Liu,Stephen M. Lewis,Martin Holcik,Myriam Gorospe +12 more
TL;DR: The posttranscriptional regulation of HIF-1α expression in human cervical carcinoma HeLa cells responding to the hypoxia mimetic CoCl2 is investigated and it is proposed that HuR and PTB jointly upregulate Hif-1 α translation in response to CoCl 2.
Journal ArticleDOI
MKP-1 mRNA Stabilization and Translational Control by RNA-Binding Proteins HuR and NF90
Yuki Kuwano,Hyeon Ho Kim,Kotb Abdelmohsen,Rudolf Pullmann,Jennifer L. Martindale,Xiaoling Yang,Myriam Gorospe +6 more
TL;DR: Collectively, MKP-1 upregulation by oxidative stress is potently influenced by increased mRNA stability and translation, mediated at least in part by the RNA-BPs HuR and NF90.
Journal ArticleDOI
Analysis of turnover and translation regulatory RNA-binding protein expression through binding to cognate mRNAs.
Rudolf Pullmann,Hyeon Ho Kim,Kotb Abdelmohsen,Ashish Lal,Jennifer L. Martindale,Xiaoling Yang,Myriam Gorospe +6 more
TL;DR: The notion that TTR-RBP expression is controlled, at least in part, at the posttranscriptional level through a complex circuitry of self- and cross-regulatory RNP interactions is underscored.