A
Ashish Lal
Researcher at National Institutes of Health
Publications - 106
Citations - 10713
Ashish Lal is an academic researcher from National Institutes of Health. The author has contributed to research in topics: microRNA & Gene. The author has an hindex of 45, co-authored 100 publications receiving 9519 citations. Previous affiliations of Ashish Lal include University of Illinois at Urbana–Champaign & Banaras Hindu University.
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Journal ArticleDOI
Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
Madhusudhanan Sukumar,Jie Liu,Yun Ji,Murugan Subramanian,Joseph G. Crompton,Zhiya Yu,Rahul Roychoudhuri,Douglas C. Palmer,Pawel Muranski,Edward D. Karoly,Robert P. Mohney,Christopher A. Klebanoff,Ashish Lal,Toren Finkel,Nicholas P. Restifo,Luca Gattinoni +15 more
TL;DR: It is indicated that augmenting glycolytic flux drives CD8+ T cells toward a terminally differentiated state, while its inhibition preserves the formation of long-lived memory CD8+, and the efficacy of T cell-based therapies against chronic infectious diseases and cancer.
Journal ArticleDOI
Long noncoding RNA MALAT1 controls cell cycle progression by regulating the expression of oncogenic transcription factor B-MYB.
Vidisha Tripathi,Zhen Shen,Arindam Chakraborty,Sumanprava Giri,Susan M. Freier,Xiaolin Wu,Yongqing Zhang,Myriam Gorospe,Supriya G. Prasanth,Ashish Lal,Kannanganattu V. Prasanth +10 more
TL;DR: It is demonstrated that MALAT1 levels are regulated during normal cell cycle progression, and mechanistic insights on the role of MALat1 in regulating cellular proliferation are provided.
Journal ArticleDOI
miR-24 Inhibits Cell Proliferation by Targeting E2F2, MYC, and Other Cell-Cycle Genes via Binding to “Seedless” 3′UTR MicroRNA Recognition Elements
Ashish Lal,Francisco Navarro,Christopher G. Maher,Laura E. Maliszewski,Nan Yan,Elizabeth M. O'Day,Dipanjan Chowdhury,Derek M. Dykxhoorn,Derek M. Dykxhoorn,Perry Tsai,Oliver Hofmann,Kevin G. Becker,Myriam Gorospe,Winston Hide,Winston Hide,Judy Lieberman +15 more
TL;DR: MiR-24, upregulated during terminal differentiation of multiple lineages, inhibits cell-cycle progression and regulates expression of E2F2, MYC, AURKB, CCNA2, CDC2, CDK4, and FEN1 by recognizing seedless but highly complementary sequences.
Journal ArticleDOI
Phosphorylation of HuR by Chk2 regulates SIRT1 expression
Kotb Abdelmohsen,Rudolf Pullmann,Ashish Lal,Hyeon Ho Kim,Stefanie Galbán,Xiaoling Yang,Justin D. Blethrow,Mark Walker,Jonathan Shubert,David A. F. Gillespie,Henry Furneaux,Myriam Gorospe +11 more
TL;DR: The findings demonstrate that HuR regulates SIRT1 expression, underscore functional links between the two stress-response proteins, and implicate Chk2 in these processes.
Journal ArticleDOI
Identification of a target RNA motif for RNA-binding protein HuR
TL;DR: The identification of a 17- to 20-base-long RNA motif rich in uracils allowed the successful prediction and subsequent validation of novel HuR targets from gene databases and presents a general strategy for identifying target motifs for RNA-binding proteins.