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Rui-Min Xu
Researcher at Zhengzhou University
Publications - 4
Citations - 202
Rui-Min Xu is an academic researcher from Zhengzhou University. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 1, co-authored 1 publications receiving 161 citations.
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Journal ArticleDOI
Triazole–Dithiocarbamate Based Selective Lysine Specific Demethylase 1 (LSD1) Inactivators Inhibit Gastric Cancer Cell Growth, Invasion, and Migration
Yi-Chao Zheng,Ying-Chao Duan,Jin-Lian Ma,Rui-Min Xu,Xiaolin Zi,Wen-Lei Lv,Meng-Meng Wang,Xian-Wei Ye,Shun Zhu,David L. Mobley,Yan-Yan Zhu,Jun-Wei Wang,Jinfeng Li,Zhi-Ru Wang,Wen Zhao,Hong-Min Liu +15 more
TL;DR: Five series of 1,2,3-triazole-dithiocarbamate hybrids were designed and synthesized and screened their inhibitory activity toward LSD1 and it was found that some of these compounds exhibited the most specific and robust inhibition of LSD1.
Journal ArticleDOI
Novel donepezil-chalcone-rivastigmine hybrids as potential multifunctional anti-Alzheimer's agents: Design, synthesis, in vitro biological evaluation, in vivo and in silico studies.
Zhipei Sang,Ping Bai,Yujuan Ban,Ker-Shi Wang,Anguo Wu,Jing Mi,Jiaqi Hu,Rui-Min Xu,Gaofeng Zhu,Jian-Ta Wang,Ji-Quan Zhang,Changning Wang,Zhenghuai Tan,Lei Tang +13 more
TL;DR: In this article , a series of novel donepezil-chalone-rivastigmine hybrids was rationally designed and synthesized by fusing didpezil, chalone and rivastigenmine, which showed significant anti-inflammation effects by suppressing the level of IL-6 and TNF-α production.
Journal ArticleDOI
Novel Donepezil-Chalcone-Rivastigmine Hybrids as Potential Multifunctional Anti-Alzheimer's Agents: Design, Synthesis, in Vitro Bilogical Evaluation, in Silico Study, Molecular Dynamics Simulation, Druggability, PET-CT Imaging Analysis and in Vivo Study
Zhipei Sang,Ping Bai,Yujuan Ban,Ker-Shi Wang,Anguo Wu,Jing Mi,Jiaqi Hu,Rui-Min Xu,Gaofeng Zhu,Jian-Ta Wang,Ji-Quan Zhang,Changning Wang,Zhenghuai Tan,Lei Tang +13 more
Posted ContentDOI
Lead change of a HIF-2α antagonist guided by multiparameter optimization and utilization of an Olp→π*Ar interaction
Paul M. Wehn,Song Yang,Jonas Grina,James P. Rizzi,Stephen T. Schlachter,Bin Wang,Rui-Min Xu,Xinlin Du,Guangzhou Han,Keshi Wang,Robert M. Czerwinski,Emily L Ged,Heli Huang,Megan M. Halfmann,Melissa A. Maddie,Emily R. Morton,Sarah R. Olive,John A. Josey,Eli M. Wallace +18 more
TL;DR: In this paper , an optimization strategy characterized by increasing the fraction of sp3 hybridized carbons (Fsp3), replacing the aromatic portion of the indane core with pyridine heterocycles, and improving a putative Olp → π*Ar interaction, an underutilized electrostatic contact in medicinal chemistry, is presented.