Z
Zhi-Ru Wang
Researcher at Zhengzhou University
Publications - 10
Citations - 719
Zhi-Ru Wang is an academic researcher from Zhengzhou University. The author has contributed to research in topics: Demethylase & Cancer cell. The author has an hindex of 7, co-authored 10 publications receiving 530 citations.
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Journal ArticleDOI
Triazole–Dithiocarbamate Based Selective Lysine Specific Demethylase 1 (LSD1) Inactivators Inhibit Gastric Cancer Cell Growth, Invasion, and Migration
Yi-Chao Zheng,Ying-Chao Duan,Jin-Lian Ma,Rui-Min Xu,Xiaolin Zi,Wen-Lei Lv,Meng-Meng Wang,Xian-Wei Ye,Shun Zhu,David L. Mobley,Yan-Yan Zhu,Jun-Wei Wang,Jinfeng Li,Zhi-Ru Wang,Wen Zhao,Hong-Min Liu +15 more
TL;DR: Five series of 1,2,3-triazole-dithiocarbamate hybrids were designed and synthesized and screened their inhibitory activity toward LSD1 and it was found that some of these compounds exhibited the most specific and robust inhibition of LSD1.
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A Systematic Review of Histone Lysine-Specific Demethylase 1 and Its Inhibitors.
Yi-Chao Zheng,Jin-Lian Ma,Zhi-Ru Wang,Jinfeng Li,Bai-Ling Jiang,Wenjuan Zhou,Xiao-Jing Shi,Wang Xixin,Wen Zhao,Hong-Min Liu +9 more
TL;DR: A review of recent studies about LSD1 focuses on the basic physiological function of LSD1 and its involved mechanisms in pathophysiologic conditions, as well as the development of LSD 1 inhibitors as potential anticancer therapeutic agents.
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Design, Synthesis, and Structure–Activity Relationship of Novel LSD1 Inhibitors Based on Pyrimidine–Thiourea Hybrids As Potent, Orally Active Antitumor Agents
Li-Ying Ma,Yi-Chao Zheng,Sai-Qi Wang,Bo Wang,Zhi-Ru Wang,L. Pang,Miao Zhang,Jun-Wei Wang,Lina Ding,Juan Li,Cong Wang,Biao Hu,Ying Liu,Xiao-Dan Zhang,Jia-Jia Wang,Zhi-Jian Wang,Wen Zhao,Hong-Min Liu +17 more
TL;DR: Findings indicate that the pyrimidine-thiourea-based LSD1 inactivator may serve as a leading compound targeting LSD1 overexpressed cancers.
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USP7: Novel Drug Target in Cancer Therapy
Zhi-Ru Wang,Wen-Ting Kang,Yinghua You,Jing-Ru Pang,Hong-Mei Ren,Zhenhe Suo,Hong-Min Liu,Yi-Chao Zheng +7 more
TL;DR: Aberrant activation or overexpression of USP7 may promote oncogenesis and viral disease, making it a target for therapeutic intervention, and may be a promising therapeutic target for the treatment of cancer.
Journal ArticleDOI
Baicalin, a natural LSD1 inhibitor.
Yi-Chao Zheng,Dan-Dan Shen,Meng Ren,Xue-Qi Liu,Zhi-Ru Wang,Ying Liu,Qian-Na Zhang,Li-Juan Zhao,Li-Jie Zhao,Jin-Lian Ma,Bin Yu,Hong-Min Liu,Hong-Min Liu +12 more
TL;DR: Baicalin was first characterized as a LSD1 inhibitor with an IC50 of 3.01μM and showed strong LSD1 inhibitory effect in cells, and may serve as a template for designing flavone-based LSD1 inhibitors.