Ying-Chao Duan

TL;DR: Flow cytometry analysis demonstrated that treatment of MGC-803 with 3c led to cell cycle arrest at G2/M phase accompanied by an increase in apoptotic cell death after 12 h, and compound 3a was more potent than 5-fluorouracil against all tested human cancer cell lines.

TL;DR: Five series of 1,2,3-triazole-dithiocarbamate hybrids were designed and synthesized and screened their inhibitory activity toward LSD1 and it was found that some of these compounds exhibited the most specific and robust inhibition of LSD1.

TL;DR: A series of novel 1,2,3-triazole-dithiocarbamate-urea hybrids were designed, synthesized and their antiproliferative activities against four selected human cancer cell lines were evaluated and showed that a number of the hybrids exhibited potent activity in selected humancancer cell lines.

TL;DR: Recently, selective degradation of target proteins by small bifunctional molecules (PROTACs) has emerged as an attractive drug discovery approach owing to the advantages it could offer over traditional small-molecule inhibitors.

TL;DR: Compound 8k showed potent and reversible inhibition against lysine specific demethylase 1 with an IC50 value of 0.39 μM, which was 74-fold more potent than that of tranylcypromine (2-PCPA) and further investigation revealed that compound 8k was active at both recombinant and cell levels by upregulating the expression of H3K4me1, H3 k4me2 and H3k9me2.