Activation of the Oxidative Stress Pathway by HIV-1 Vpr Leads to Induction of Hypoxia-inducible Factor 1α Expression
Satish L. Deshmane,Ruma Mukerjee,Shongshan Fan,Luis Del Valle,Carine Michiels,Thersa Sweet,Inna Rom,Kamel Khalili,Jay Rappaport,Shohreh Amini,Bassel E. Sawaya +10 more
TLDR
The results point to the activation of hypoxia-inducible factor 1 (HIF-1) upon HIV-1 infection and its elevation in brain cells of AIDS patients with dementia and that, by inducing oxidative stress via activation of Hif-1, Vpr can induce HIV- 1 gene expression and dysregulate multiple host cellular pathways.About:
This article is published in Journal of Biological Chemistry.The article was published on 2009-04-24 and is currently open access. It has received 107 citations till now. The article focuses on the topics: Oxidative Stress Pathway & Oxidative stress.read more
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HIF Transcription Factors, Inflammation, and Immunity
Asis Palazon,Ananda W. Goldrath,Victor Nizet,Victor Nizet,Randall S. Johnson,Randall S. Johnson +5 more
TL;DR: How oxygen sensing in the immune microenvironment shapes immunological response is discussed and how HIF and the hypoxia pathway control innate and adaptive immunity is examined.
Journal ArticleDOI
Oxidative Stress during HIV Infection: Mechanisms and Consequences
Alexander V. Ivanov,Vladimir T. Valuev-Elliston,Olga N. Ivanova,Sergey N. Kochetkov,Elizaveta Starodubova,Birke Bartosch,Maria G. Isaguliants +6 more
TL;DR: Current state of knowledge on the redox alterations as crucial factors of HIV-1 pathogenicity, such as neurotoxicity and dementia, exhaustion of CD4+/CD8+ T-cells, predisposition to lung infections, and certain side effects of the antiretroviral therapy are presented and compared to the pathologies associated with the nitrosative stress.
Journal ArticleDOI
The Role of HIF in Immunity and Inflammation
TL;DR: The role of HIF is reviewed, including its role in macrophages, dendritic cells, neutrophils, T cells, and B cells, with HIF being implicated in multiple inflammatory diseases and in immunosuppression in tumors.
Journal ArticleDOI
How Viral and Intracellular Bacterial Pathogens Reprogram the Metabolism of Host Cells to Allow Their Intracellular Replication.
TL;DR: This review compares the present knowledge on this important, yet still poorly understood aspect of pathogenesis of human viral and especially IBP infections with that oncogenes and tumor suppressors.
Journal ArticleDOI
Role of oxidative stress in infectious diseases. A review
TL;DR: The basic pathways in which reactive species can accumulate during infectious diseases are reviewed and the related health consequences are discussed.
References
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Hypoxia-inducible factor-1 (HIF-1).
Qingdong Ke,Max Costa +1 more
TL;DR: Overexpression of HIF-1 has been found in various cancers, and targeting Hif-1 could represent a novel approach to cancer therapy.
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Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit
TL;DR: Results suggest that an intact redox-dependent signaling pathway is required for destablization of the HIF-1α protein, which was rapidly and drastically decreased in vivo following an abrupt increase to normal oxygen tension.
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The signaling mechanism of ROS in tumor progression
TL;DR: Comprehensive understanding of the ROS-triggered signaling transduction, transcriptional activation and regulation of gene expressions will help strengthen the critical role of ROS in tumor progression and devising strategy for chemo-therapeutic interventions.
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Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression
Yuichi Makino,Renhai Cao,Kristian Svensson,Göran Bertilsson,Mikael Asman,Hirotoshi Tanaka,Yihai Cao,Anders Berkenstam,Lorenz Poellinger +8 more
TL;DR: An inhibitory PAS (Per/Arnt/Sim) domain protein, IPAS, which is a basic helix-loop-helix (bHLH)/PAS protein structurally related to HIFs, is described, which demonstrates dominant negative regulation of HIF-mediated control of gene expression.
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Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site.
Steve Bonello,Christian Zähringer,Rachida S. BelAiba,Talija Djordjevic,John R. Hess,Carine Michiels,Thomas Kietzmann,Agnes Görlach +7 more
TL;DR: It is shown for the first time to the authors' knowledge that reactive oxygen species directly link HIF-1&agr; and NF-&kgr;B, implicating an important pathophysiological role of this novel pathway in disorders associated with elevated levels of reactive oxygen Species.