Ryan D. White

TL;DR: It is shown that leptin depolarizes and increases the firing rate of steroidogenic factor-1 (SF1)-positive neurons in the VMH, and that leptin action at this site plays an important role in reducing body weight and, of note, in resisting diet-induced obesity.

TL;DR: It is shown that when fed a high-fat diet, both female and male GHSR-null mice eat less food, store less of their consumed calories, preferentially utilize fat as an energy substrate, and accumulate less body weight and adiposity than control mice, which supports the hypothesis that ghrelin-responsive pathways are an important component of coordinated body weight control.

TL;DR: This was a randomised, double-blind, placebo-controlled trial done in the USA, Romania, and Moldova in 2020–2021, before the emergence of omicron-lineage variants and reduced the risk of COVID-19 by 81·2% (nominal p<0·0001) versus placebo (prespecified analysis).