S
Streamson C. Chua
Researcher at Albert Einstein College of Medicine
Publications - 154
Citations - 16607
Streamson C. Chua is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Leptin & Leptin receptor. The author has an hindex of 60, co-authored 153 publications receiving 15336 citations. Previous affiliations of Streamson C. Chua include Rockefeller University & Yeshiva University.
Papers
More filters
Journal ArticleDOI
Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor
Streamson C. Chua,Wendy K. Chung,X. Sharon Wu-Peng,Yiying Zhang,Shun Mei Liu,Louis A. Tartaglia,Rudolph L. Leibel +6 more
TL;DR: The cloning of ob, and the demonstration that it encodes a secreted protein that binds specifically to a receptor (OB-R) in the brain, have validated critical aspects of this hypothesis.
Journal ArticleDOI
Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons.
TL;DR: This work takes an alternative approach and tests whether first-order neurons are inhibitory (GABAergic, VGAT⁺) or excitatory (glutamatergic, VGLUT2⁺), which mediates the vast majority of leptin's antiobesity effects.
Journal ArticleDOI
Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI†
Tayeba Khan,Eric S. Muise,Puneeth Iyengar,Puneeth Iyengar,Zhao V. Wang,Manisha Chandalia,Nicola Abate,Bei B. Zhang,Paolo Bonaldo,Streamson C. Chua,Philipp E. Scherer +10 more
TL;DR: It is suggested that weakening the extracellular scaffold of adipocytes enables their stress-free expansion during states of positive energy balance, which is consequently associated with an improved inflammatory profile and implicating “adipose tissue fibrosis” as a hallmark of metabolically challenged adipocytes.
Journal ArticleDOI
Leptin Receptor Signaling in POMC Neurons Is Required for Normal Body Weight Homeostasis
Nina Balthasar,Roberto Coppari,Julie E. McMinn,Shun M. Liu,Charlotte E. Lee,Vinsee Tang,Christopher D. Kenny,Robert A. McGovern,Streamson C. Chua,Joel K. Elmquist,Bradford B. Lowell +10 more
TL;DR: Leptin receptors on POMC neurons are required but not solely responsible for leptin's regulation of body weight homeostasis, as tested using the Cre/loxP system.
Journal ArticleDOI
Leptin Directly Activates SF1 Neurons in the VMH, and This Action by Leptin Is Required for Normal Body-Weight Homeostasis
Harveen Dhillon,Jeffrey M. Zigman,Chianping Ye,Charlotte E. Lee,Robert A. McGovern,Vinsee Tang,Christopher D. Kenny,Lauryn M. Christiansen,Ryan D. White,Elisabeth A. Edelstein,Roberto Coppari,Nina Balthasar,Michael A. Cowley,Streamson C. Chua,Joel K. Elmquist,Bradford B. Lowell +15 more
TL;DR: It is shown that leptin depolarizes and increases the firing rate of steroidogenic factor-1 (SF1)-positive neurons in the VMH, and that leptin action at this site plays an important role in reducing body weight and, of note, in resisting diet-induced obesity.