R
Ryosuke Nakamura
Researcher at Tohoku University
Publications - 62
Citations - 1156
Ryosuke Nakamura is an academic researcher from Tohoku University. The author has contributed to research in topics: Immunoglobulin E & Toxic epidermal necrolysis. The author has an hindex of 17, co-authored 60 publications receiving 983 citations.
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Journal ArticleDOI
Genetic variants associated with phenytoin-related severe cutaneous adverse reactions
Wen-Hung Chung,Wen-Hung Chung,Wan-Chun Chang,Yun-Shien Lee,Ying Ying Wu,Chih Hsun Yang,Chih Hsun Yang,Hsin Chun Ho,Hsin Chun Ho,Ming Jing Chen,Ming Jing Chen,Jing-Yi Lin,Jing-Yi Lin,Rosaline Chung-Yee Hui,Rosaline Chung-Yee Hui,Ji Chen Ho,Ji Chen Ho,Wei Ming Wu,Wei Ming Wu,Ting Jui Chen,Ting Jui Chen,Tony Wu,Tony Wu,Yih Ru Wu,Yih Ru Wu,Mo Song Hsih,Mo Song Hsih,Po Hsun Tu,Po Hsun Tu,Chen Nen Chang,Chen Nen Chang,Chien Ning Hsu,Chien Ning Hsu,Tsu Lan Wu,Tsu Lan Wu,Siew Eng Choon,Chao Kai Hsu,Der-Yuan Chen,Chin San Liu,Ching-Yuang Lin,Nahoko Kaniwa,Yoshiro Saito,Yukitoshi Takahashi,Ryosuke Nakamura,Hiroaki Azukizawa,Yongyong Shi,Tzu Hao Wang,Tzu Hao Wang,Shiow Shuh Chuang,Shiow Shuh Chuang,Shih Feng Tsai,Chee-Jen Chang,Chee-Jen Chang,Yu-Sun Chang,Shuen-Iu Hung +54 more
TL;DR: Delayed clearance of plasma phenytoin was detected in patients with severe cutaneous adverse reactions, especially CYP2C9*3 carriers, providing a functional link of the associated variants to the disease.
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Independent strong association of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe mucosal involvement
Mayumi Ueta,Nahoko Kaniwa,Chie Sotozono,Katsushi Tokunaga,Yoshiro Saito,Hiromi Sawai,Hiroko Miyadera,Emiko Sugiyama,Keiko Maekawa,Ryosuke Nakamura,Masaki Nagato,Michiko Aihara,Kayoko Matsunaga,Yukitoshi Takahashi,Hirokazu Furuya,Masaaki Muramatsu,Zenrou Ikezawa,Shigeru Kinoshita +17 more
TL;DR: Investigation of the association between HLA genotypes and cold medicine-related Stevens-Johnson syndrome patients suggested that these two susceptibility alleles are involved in the development of only CM-SJS/TEN with SOC patients.
Journal ArticleDOI
A convenient and sensitive allergy test: IgE crosslinking‐induced luciferase expression in cultured mast cells
TL;DR: A convenient and sensitive allergy test: IgE crosslinking–induced luciferase expression in cultured mast cells is shown to be a viable alternative to traditional allergy tests.
Journal ArticleDOI
IKZF1, a new susceptibility gene for cold medicine–related Stevens-Johnson syndrome/toxic epidermal necrolysis with severe mucosal involvement
Mayumi Ueta,Mayumi Ueta,Mayumi Ueta,Hiromi Sawai,Chie Sotozono,Yuki Hitomi,Nahoko Kaniwa,Mee Kum Kim,Kyoung Yul Seo,Kyung Chul Yoon,Choun Ki Joo,Chitra Kannabiran,Tais Hitomi Wakamatsu,Virender S Sangwan,Varsha M Rathi,Sayan Basu,Takeshi Ozeki,Taisei Mushiroda,Emiko Sugiyama,Keiko Maekawa,Ryosuke Nakamura,Michiko Aihara,Kayoko Matsunaga,Akihiro Sekine,José Álvaro Pereira Gomes,Junji Hamuro,Yoshiro Saito,Michiaki Kubo,Shigeru Kinoshita,Katsushi Tokunaga +29 more
TL;DR: In this paper, the authors identified IKZF1 as a susceptibility gene for cold medicine-related Stevens-Johnson syndrome (SJS) with severe mucosal involvement (SMI), and subsequent replication studies were performed in 204 other Japanese subjects, 117 Korean subjects, 27 cases and 90 control subjects, 76 Indian subjects (20 cases and 56 control subjects), and 174 Brazilian subjects (39 cases and 135 control subjects).
Journal ArticleDOI
HLA Alleles and CYP2C9*3 as Predictors of Phenytoin Hypersensitivity in East Asians
Shih-Chi Su,Chun-Bing Chen,Wan-Chun Chang,Chuang-Wei Wang,Chuang-Wei Wang,Wen-Lang Fan,Lai-Ying Lu,Lai-Ying Lu,Ryosuke Nakamura,Yoshiro Saito,Mayumi Ueta,Shigeru Kinoshita,Chonlaphat Sukasem,Kittika Yampayon,Kittika Yampayon,Pornpimol Kijsanayotin,Nontaya Nakkam,Niwat Saksit,Wichittra Tassaneeyakul,Michiko Aihara,Yu-Jr Lin,Chee-Jen Chang,Tony Wu,Shuen-Iu Hung,Wen-Hung Chung +24 more
TL;DR: Combining the assessment of risk alleles of HLA and CYP2C9 potentiated the usefulness of predictive genetic tests to prevent phenytoin hypersensitivity in Asians.