S
S Böttcher
Researcher at Erasmus University Medical Center
Publications - 17
Citations - 4143
S Böttcher is an academic researcher from Erasmus University Medical Center. The author has contributed to research in topics: Minimal residual disease & Chronic lymphocytic leukemia. The author has an hindex of 15, co-authored 17 publications receiving 3596 citations.
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Journal ArticleDOI
Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial
Michael Hallek,Kirsten Fischer,Günter Fingerle-Rowson,Anna-Maria Fink,Raymonde Busch,Jiří Mayer,Manfred Hensel,Georg Hopfinger,G D Hess,U. Von Grünhagen,Matthias Bergmann,John Catalano,Pier Luigi Zinzani,Federico Caligaris-Cappio,John F. Seymour,Alain Berrebi,Ulrich Jäger,Bruno Cazin,Marek Trneny,Anne Westermann,Clemens M. Wendtner,Barbara Eichhorst,Peter Staib,Andreas Bühler,Dirk Winkler,Thorsten Zenz,S Böttcher,Matthias Ritgen,Myriam Mendila,Michael Kneba,Hartmut Döhner,Stephan Stilgenbauer +31 more
TL;DR: Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab improves progression-free survival and overall survival in patients with chronic lymphocytic leukaemia, and the results suggest that the choice of a specific first-line treatment changes the natural course of chronic lymphocytes.
Journal ArticleDOI
EuroFlow antibody panels for standardized n-dimensional flow cytometric immunophenotyping of normal, reactive and malignant leukocytes.
J. J. M. Van Dongen,Ludovic Lhermitte,S Böttcher,Julia Almeida,V H J van der Velden,Juan Flores-Montero,Andy C. Rawstron,Vahid Asnafi,Quentin Lecrevisse,Paulo Sérgio Lucio,Ester Mejstrikova,Tomasz Szczepański,Tomas Kalina,R de Tute,Monika Brüggemann,Lukasz Sedek,M Cullen,Anthonie Willem Langerak,Alexandre de Mendonça,Elizabeth Macintyre,Marta Martin-Ayuso,Ondrej Hrusak,M B Vidriales,Alberto Orfao +23 more
TL;DR: The EuroFlow studies resulted in validated and flexible 8-color antibody panels for multidimensional identification and characterization of normal and aberrant cells, optimally suited for immunophenotypic screening and classification of hematological malignancies.
Journal ArticleDOI
EuroFlow standardization of flow cytometer instrument settings and immunophenotyping protocols
Tomas Kalina,Juan Flores-Montero,V H J van der Velden,Marta Martin-Ayuso,S Böttcher,Matthias Ritgen,Julia Almeida,Ludovic Lhermitte,Vahid Asnafi,Alexandre de Mendonça,R de Tute,M Cullen,Lukasz Sedek,M B Vidriales,J.J. Pérez,J. G. te Marvelde,Ester Mejstrikova,Ondrej Hrusak,T Szczepa nacute,ski,J. J. M. Van Dongen,Alberto Orfao +21 more
TL;DR: The 6 years of extensive collaborative experiments and the analysis of hundreds of cell samples of patients and healthy controls have provided for the first time laboratory protocols and software tools for fully standardized 8-color flow cytometric immunophenotyping of normal and malignant leukocytes in bone marrow and blood; this has yielded highly comparable data sets, which can be integrated in a single database.
Journal ArticleDOI
Next Generation Flow for highly sensitive and standardized detection of minimal residual disease in multiple myeloma
Juan Flores-Montero,Luzalba Sanoja-Flores,Bruno Paiva,N. Puig,O García-Sánchez,S Böttcher,V H J van der Velden,J-J Pérez-Morán,M B Vidriales,Ramón García-Sanz,Carmen Jiménez,Marcos González,Joaquin Martinez-Lopez,Alba Corral-Mateos,G-E Grigore,Rafael Fluxa,Roberia Pontes,Joana Caetano,Lukasz Sedek,M-C del Cañizo,J. Bladé,J. J. Lahuerta,Carlos Aguilar,Abelardo Bárez,Aránzazu García-Mateo,Jorge Labrador,Pilar Leoz,C Aguilera-Sanz,Jesús F. San-Miguel,M.V. Mateos,Brian G.M. Durie,J. J. M. Van Dongen,J. J. M. Van Dongen,Alberto Orfao +33 more
TL;DR: EuroFlow-based NGF is established as a highly sensitive, fully standardized approach for MRD detection in MM which overcomes the major limitations of conventional flow-MRD methods and is ready for implementation in routine diagnostics.
Journal ArticleDOI
Improving efficiency and sensitivity: European Research Initiative in CLL (ERIC) update on the international harmonised approach for flow cytometric residual disease monitoring in CLL
Andy C. Rawstron,Andy C. Rawstron,S Böttcher,Rémi Letestu,Neus Villamor,Claudia Fazi,H. Kartsios,R de Tute,Jane Shingles,Matthias Ritgen,C Moreno,Ke Lin,Andrew R. Pettitt,Michael Kneba,Emili Montserrat,Florence Cymbalista,Michael Hallek,Peter Hillmen,Paolo Ghia +18 more
TL;DR: This study identifies situations where a less time-consuming CD19/CD5/κ/λ analysis would be sufficient for detecting residual CLL, and develops a six-CLR antibody panel that is more efficient for cases requiring full MRD analysis.