M
M Cullen
Researcher at University of Leeds
Publications - 3
Citations - 1466
M Cullen is an academic researcher from University of Leeds. The author has contributed to research in topics: EuroFlow & Cellular differentiation. The author has an hindex of 3, co-authored 3 publications receiving 1201 citations.
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Journal ArticleDOI
EuroFlow antibody panels for standardized n-dimensional flow cytometric immunophenotyping of normal, reactive and malignant leukocytes.
J. J. M. Van Dongen,Ludovic Lhermitte,S Böttcher,Julia Almeida,V H J van der Velden,Juan Flores-Montero,Andy C. Rawstron,Vahid Asnafi,Quentin Lecrevisse,Paulo Sérgio Lucio,Ester Mejstrikova,Tomasz Szczepański,Tomas Kalina,R de Tute,Monika Brüggemann,Lukasz Sedek,M Cullen,Anthonie Willem Langerak,Alexandre de Mendonça,Elizabeth Macintyre,Marta Martin-Ayuso,Ondrej Hrusak,M B Vidriales,Alberto Orfao +23 more
TL;DR: The EuroFlow studies resulted in validated and flexible 8-color antibody panels for multidimensional identification and characterization of normal and aberrant cells, optimally suited for immunophenotypic screening and classification of hematological malignancies.
Journal ArticleDOI
EuroFlow standardization of flow cytometer instrument settings and immunophenotyping protocols
Tomas Kalina,Juan Flores-Montero,V H J van der Velden,Marta Martin-Ayuso,S Böttcher,Matthias Ritgen,Julia Almeida,Ludovic Lhermitte,Vahid Asnafi,Alexandre de Mendonça,R de Tute,M Cullen,Lukasz Sedek,M B Vidriales,J.J. Pérez,J. G. te Marvelde,Ester Mejstrikova,Ondrej Hrusak,T Szczepa nacute,ski,J. J. M. Van Dongen,Alberto Orfao +21 more
TL;DR: The 6 years of extensive collaborative experiments and the analysis of hundreds of cell samples of patients and healthy controls have provided for the first time laboratory protocols and software tools for fully standardized 8-color flow cytometric immunophenotyping of normal and malignant leukocytes in bone marrow and blood; this has yielded highly comparable data sets, which can be integrated in a single database.
Journal ArticleDOI
Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding
Anetta Ptasinska,Salam A. Assi,D Mannari,Sally R. James,Daniel Williamson,J Dunne,Maarten Hoogenkamp,Mengchu Wu,Matthew A. Care,Hesta McNeill,Pierre Cauchy,M Cullen,Reuben Tooze,Daniel G. Tenen,Daniel G. Tenen,Bryan D. Young,Peter N. Cockerill,Peter N. Cockerill,David R. Westhead,Olaf Heidenreich,Constanze Bonifer,Constanze Bonifer +21 more
TL;DR: It is shown that selective removal of RUNX1/ETO leads to a widespread reversal of epigenetic reprogramming and a genome-wide redistribution of RunX1 binding, resulting in the inhibition of leukemic proliferation and self-renewal, and the induction of differentiation.