Journal ArticleDOI
The Potential of Secondary Metabolites from Plants as Drugs or Leads Against Protozoan Neglected Diseases – Part I
Thomas J. Schmidt,Sami A. Khalid,Alvaro J. Romanha,T. Ma. Alves,Maique W. Biavatti,Reto Brun,FB Da Costa,S. L. De Castro,Vitor F. Ferreira,M. V. G. de Lacerda,João Henrique G. Lago,Leonor L. Leon,Norberto Peporine Lopes,R. C. das Neves Amorim,Michael Niehues,Ifedayo Victor Ogungbe,Adrian Martin Pohlit,Marcus Tullius Scotti,William N. Setzer,M. de N. C. Soeiro,M. Steindel,Andre G. Tempone +21 more
TLDR
The current review attempts to give an overview on the potential of such plant-derived natural products as antiprotozoal leads and/or drugs in the fight against NTDs.Abstract:
Infections with protozoan parasites are a major cause of disease and mortality in many tropical countries of the world. Diseases caused by species of the genera Trypanosoma (Human African Trypanosomiasis and Chagas Disease) and Leishmania (various forms of Leishmaniasis) are among the seventeen "Neglected Tropical Diseases" (NTDs) defined by the WHO. Furthermore, malaria (caused by various Plasmodium species) can be considered a neglected disease in certain countries and with regard to availability and affordability of the antimalarials. Living organisms, especially plants, provide an innumerable number of molecules with potential for the treatment of many serious diseases. The current review attempts to give an overview on the potential of such plant-derived natural products as antiprotozoal leads and/or drugs in the fight against NTDs. In part I, a general description of the diseases, the current state of therapy and need for new therapeuticals, assay methods and strategies applied in the search for new plant derived natural products against these diseases and an overview on natural products of terpenoid origin with antiprotozoal potential were given. The present part II compiles the current knowledge on natural products with antiprotozoal activity that are derived from the shikimate pathway (lignans, coumarins, caffeic acid derivatives), quinones of various structural classes, compounds formed via the polyketide pathways (flavonoids and related compounds, chromenes and related benzopyrans and benzofurans, xanthones, acetogenins from Annonaceae and polyacetylenes) as well as the diverse classes of alkaloids. In total, both parts compile the literature on almost 900 different plant-derived natural products and their activity data, taken from over 800 references. These data, as the result of enormous efforts of numerous research groups world-wide, illustrate that plant secondary metabolites represent an immensely rich source of chemical diversity with an extremely high potential to yield a wealth of lead structures towards new therapies for NTDs. Only a small percentage, however, of the roughly 200,000 plant species on earth have been studied chemically and only a small percentage of these plants or their constituents has been investigated for antiprotozoal activity. The repository of plant-derived natural products hence deserves to be investigated even more intensely than it has been up to present.read more
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[Expression of fusion proteins in beta(2)GP I gene-transfected HEp-2 cells and its clinical application].
Liangjing Lu,Shunle Chen,Yue-ying Gu,Nan Shen,Chunde Bao,Yuan Wang,Chengde Yang,Ping Ye,Chong-zhao Yu +8 more
TL;DR: As a new kind of substrate of IIF, beta( 2)GP I transfectant can be used to detect anti-beta(2)GP-I antibodies and keep the immunofluorescent property of HEp-2 cells in IFANA test and can be use as substrate for routine IFANA detection.
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Comprehensive review of antimicrobial activities of plant flavonoids
TL;DR: The development and application of flavonoid-based drugs could be a promising approach for antibiotic-resistant infections and improve understanding of the biological and molecular roles of plant flavonoids, focusing mostly on their antimicrobial activities.
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Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis.
Advait Nagle,Shilpi Khare,Arun Kumar,Frantisek Supek,Andriy Buchynskyy,Casey J. N. Mathison,Naveen Kumar Chennamaneni,Nagendar Pendem,Frederick S. Buckner,Michael H. Gelb,Valentina Molteni +10 more
TL;DR: The disease history and parasite biology is described followed by a summary of the currently available treatments and, finally, review reports of novel small molecules with antileishmanial activity.
Journal ArticleDOI
Secondary metabolites in floral nectar reduce parasite infections in bumblebees
Leif L. Richardson,Lynn S. Adler,Anne S. Leonard,Jonathan Andicoechea,Karly H. Regan,Winston E. Anthony,Jessamyn S. Manson,Rebecca E. Irwin +7 more
TL;DR: The novel results highlight that although secondary metabolites may not rescue survival in infected bees, they may play a vital role in mediating Crithidia transmission within and between colonies by reducingCrithidia infection intensities.
Journal ArticleDOI
Plant Phenolics and Phenolic-Enriched Extracts as Antimicrobial Agents against Food-Contaminating Microorganisms
Miklós Takó,Erika Beáta Kerekes,Carolina Zambrano,Alexandra Kotogán,Tamás Papp,Judit Krisch,Csaba Vágvölgyi +6 more
TL;DR: The antimicrobial,anti-quorum sensing, anti-biofilm and anti-enterotoxin activities, of plant phenolic extracts and compounds are discussed, with special attention to pathogen microorganisms that have food relation.
References
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Journal ArticleDOI
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Journal Article
The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer
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Journal ArticleDOI
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