J
João Henrique G. Lago
Researcher at Universidade Federal do ABC
Publications - 293
Citations - 5816
João Henrique G. Lago is an academic researcher from Universidade Federal do ABC. The author has contributed to research in topics: Chemistry & Trypanosoma cruzi. The author has an hindex of 34, co-authored 260 publications receiving 4638 citations. Previous affiliations of João Henrique G. Lago include Mackenzie Presbyterian University & Federal University of Piauí.
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Journal ArticleDOI
The Potential of Secondary Metabolites from Plants as Drugs or Leads Against Protozoan Neglected Diseases – Part I
Thomas J. Schmidt,Sami A. Khalid,Alvaro J. Romanha,T. Ma. Alves,Maique W. Biavatti,Reto Brun,FB Da Costa,S. L. De Castro,Vitor F. Ferreira,M. V. G. de Lacerda,João Henrique G. Lago,Leonor L. Leon,Norberto Peporine Lopes,R. C. das Neves Amorim,Michael Niehues,Ifedayo Victor Ogungbe,Adrian Martin Pohlit,Marcus Tullius Scotti,William N. Setzer,M. de N. C. Soeiro,M. Steindel,Andre G. Tempone +21 more
TL;DR: The current review attempts to give an overview on the potential of such plant-derived natural products as antiprotozoal leads and/or drugs in the fight against NTDs.
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Benzoic Acid Derivatives from Piper Species and Their Fungitoxic Activity against Cladosporium cladosporioides and C. sphaerospermum
João Henrique G. Lago,Clécio Sousa Ramos,Diego Campos C. Casanova,Andreia de A. Morandim,Debora Cristina B. Bergamo,Alberto José Cavalheiro,Vanderlan da Silva Bolzani,Maysa Furlan,Elsie F. Guimarães,Maria Claudia Marx Young,Massuo J. Kato +10 more
TL;DR: Piper crassinervium, P. aduncum,P.
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Antimicrobial Activity of Oleanolic and Ursolic Acids: An Update
Jéssica Adriana Jesus,João Henrique G. Lago,Márcia Dalastra Laurenti,Eduardo S. Yamamoto,Luiz Felipe Domingues Passero +4 more
TL;DR: The potential use of these triterpenes against human pathogens, including their mechanisms of action, via in vivo studies, and the future perspectives about the use of compounds for human or even animal health are discussed.
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α-Pinene isolated from Schinus terebinthifolius Raddi (Anacardiaceae) induces apoptosis and confers antimetastatic protection in a melanoma model.
Alisson L. Matsuo,Carlos R. Figueiredo,Denise C. Arruda,Felipe V. Pereira,Jorge Augusto Borin Scutti,Mariana H. Massaoka,Luiz R. Travassos,Patricia Sartorelli,João Henrique G. Lago +8 more
TL;DR: It is demonstrated that α-pinene was able to induce apoptosis evidenced by early disruption of the mitochondrial potential, production of reactive oxygen species, increase in caspase-3 activity, heterochromatin aggregation, DNA fragmentation and exposure of phosphatidyl serine on the cell surface.
Journal ArticleDOI
Structure-Activity Association of Flavonoids in Lung Diseases
João Henrique G. Lago,Alessandra Choqueta de Toledo-Arruda,Marcia Mernak,Kaidu H. Barrosa,Milton A. Martins,Iolanda F.L.C. Tibério,Carla Máximo Prado +6 more
TL;DR: The effects of different flavonoids in the control of lung inflammation in some disorders such as asthma, lung emphysema and acute respiratory distress syndrome are discussed and some structure-activity relationships between this biological potential and chemical profile of these compounds are established.